Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons.

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作者： Wei,Lin ^[1] ; Wen-Wen,Zhang ^[1] ; Ning,Lyu ^[2] ; Hong,Cao ^[1] ; Wen-Dong,Xu ^[3] ; Yu-Qiu,Zhang ^[4]

作者单位： Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai, 200032, China. ^[1] Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai, 200032, China. ninglu@fudan.edu.cn. ^[2] Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai, 200032, China. wendongxu@fudan.edu.cn. ^[3] Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. wendongxu@fudan.edu.cn. ^[4] Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai, 200032, China. yuqiuzhang@fudan.edu.cn. ^[5] Department of Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China. yuqiuzhang@fudan.edu.cn. ^[6]

关键词 Activin receptor-like kinase-2 Dorsal root ganglion Growth differentiation factor-15 Pain Tetrodotoxin-resistant sodium channel Nav1.8 Whole-cell recording

主题词镇痛(Analgesia);动物(Animals);神经节, 脊(Ganglia, Spinal);生长分化因子15(Growth Differentiation Factor 15);大鼠(Rats);感觉感受器细胞(Sensory Receptor Cells);钠通道(Sodium Channels);河豚毒素(Tetrodotoxin)

DOI 10.1007/s12264-021-00709-5

PMID 34076854

发布时间 2021-09-30

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Neuroscience bulletin

2021年37卷9期

1289-1302页

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Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons.

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Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons.

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