Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study.
第一作者:
Katja,von Hoff
第一单位:
Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
作者:
Katja,von Hoff [1]
;
Christine,Haberler [2]
;
Felix,Schmitt-Hoffner [3]
;
Elizabeth,Schepke [4]
;
Teresa,de Rojas [5]
;
Sandra,Jacobs [6]
;
Michal,Zapotocky [7]
;
David,Sumerauer [7]
;
Marta,Perek-Polnik [8]
;
Christelle,Dufour [9]
;
Dannis,van Vuurden [10]
;
Irene,Slavc [11]
;
Johannes,Gojo [11]
;
Jessica C,Pickles [12]
;
Nicolas U,Gerber [13]
;
Maura,Massimino [14]
;
Maria Joao,Gil-da-Costa [15]
;
Miklos,Garami [16]
;
Ella,Kumirova [17]
;
Astrid,Sehested [18]
;
David,Scheie [19]
;
Ofelia,Cruz [20]
;
Lucas,Moreno [21]
;
Jaeho,Cho [22]
;
Bernward,Zeller [23]
;
Niels,Bovenschen [24]
;
Michael,Grotzer [13]
;
Daniel,Alderete [25]
;
Matija,Snuderl [26]
;
Olga,Zheludkova [27]
;
Andrey,Golanov [28]
;
Konstantin,Okonechnikov [29]
;
Martin,Mynarek [30]
;
Björn Ole,Juhnke [30]
;
Stefan,Rutkowski [30]
;
Ulrich,Schüller [31]
;
Barry,Pizer [32]
;
Barbara,von Zezschwitz [1]
;
Robert,Kwiecien [33]
;
Maximilian,Wechsung [34]
;
Frank,Konietschke [34]
;
Eugene I,Hwang [35]
;
Dominik,Sturm [36]
;
Stefan M,Pfister [37]
;
Andreas,von Deimling [38]
;
Elisabeth J,Rushing [39]
;
Marina,Ryzhova [40]
;
Peter,Hauser [16]
;
Maria,Łastowska [41]
;
Pieter,Wesseling [42]
;
Felice,Giangaspero [43]
;
Cynthia,Hawkins [44]
;
Dominique,Figarella-Branger [45]
;
Charles,Eberhart [46]
;
Peter,Burger [46]
;
Marco,Gessi [47]
;
Andrey,Korshunov [38]
;
Tom S,Jacques [48]
;
David,Capper [49]
;
Torsten,Pietsch [50]
;
Marcel,Kool [51]
作者单位:
Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
[1]
Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.
[2]
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.;Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
[3]
The Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
[4]
Pediatric OncoGenomics Unit, Children's University Hospital Niño Jesús, Madrid, Spain.
[5]
Department of Pediatrics, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
[6]
Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
[7]
Department of Oncology, The Children's Memorial Health Institute, University of Warsaw, Warsaw, Poland.
[8]
Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Center, Villejuif, France.;INSERM, Molecular Predictors and New Targets in Oncology, Paris-Saclay University, Villejuif, France.
[9]
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
[10]
Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.
[11]
Developmental Biology and Cancer Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.;Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
[12]
Department of Oncology, University Children's Hospital, Zurich, Switzerland.
[13]
Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
[14]
Pediatric Oncology Department, University Hospital São João, Porto, Portugal.
[15]
2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
[16]
Department of Neuro-Oncology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
[17]
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen,Denmark.
[18]
Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
[19]
Pediatric Oncology Department, Hospital Sant Joan de Déu, Barcelona, Spain.
[20]
Paediatric Haematology and Oncology Division, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
[21]
Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
[22]
Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.
[23]
Department of Pathology, University Medical Centre Utrecht, Utrecht, the Netherlands.
[24]
Service of Hematology/Oncology, Hospital JP Garrahan, Buenos Aires, Argentina.
[25]
Department of Pathology, NYU Langone Health and School of Medicine, New York, New York, USA.
[26]
Department of Neurooncology, Russian Scientific Center of Radiology, Moscow, Russia.
[27]
Department of Neuroradiology, Burdenko Neurosurgical Institute, Moscow, Russia.
[28]
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
[29]
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[30]
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.
[31]
Institute of Translational Research, University of Liverpool, Liverpool, UK.
[32]
Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany.
[33]
Institute of Biometry and Clinical Epidemiology, Charité University Medicine and Berlin Institute of Health, Berlin, Germany.
[34]
Department of Pediatric Hematology-Oncology, Center for Cancer and Immunology Research and Neuroscience Research, Children's National Medical Center, Washington DC, USA.
[35]
Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.;Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
[36]
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.;Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
[37]
Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[38]
Institute of Neuropathology, University Medical Center Zurich, Zurich, Switzerland.
[39]
Department of Neuropathology, Burdenko Neurosurgical Institute, Moscow, Russia.
[40]
Department of Pathomorphology, Children's Memorial Health Institute, Warsaw, Poland.
[41]
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.;Department of Pathology, Amsterdam University Medical Center/VUmc, Amsterdam, the Netherlands.
[42]
Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.;IRCCS Neuromed, Pozzilli (IS), Italy.
[43]
Division of Pathology, The Hospital for Sick Children, Toronto, Canada.
[44]
Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Aix-Marseille Univ, APHM, CNRS, INP, Marseille, France.
[45]
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
[46]
Neuropathology Unit, Division of Pathology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
[47]
Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
[48]
Department of Neuropathology, Charité University Medicine and Berlin Institute of Health, Berlin, Germany.;German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[49]
Department of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn, DZNE German Center for Neurodegenerative Diseases, Bonn, Germany.
[50]
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.;Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
[51]
主题词
脑肿瘤(Brain Neoplasms);中枢神经系统肿瘤(Central Nervous System Neoplasms);叉头转录因子类(Forkhead Transcription Factors);人类(Humans);肿瘤, 生殖细胞和胚胎性(Neoplasms, Germ Cell and Embryonal);神经外胚瘤, 原始(Neuroectodermal Tumors, Primitive);病理学, 分子(Pathology, Molecular);回顾性研究(Retrospective Studies)
DOI
10.1093/neuonc/noab136
PMID
34077956
发布时间
2022-07-16
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Neuro-oncology
Neuro-oncology
1597-1611页
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