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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

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作者单位: Cancer Research UK Beatson Institute, Glasgow, UK. [1] Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. [2] Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. [3] Alzheimer's Research UK UCL Drug Discovery Institute, University College London, London, UK. [4] SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA. [5] Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden. [6] Intestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK. [7] Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. [8] Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. [9] Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France. [10] Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK. [11] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands. [12] Department of Pathology, Applied Tumor Genomics, Research Programs Unit and HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. [13] Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. [14] Wihuri Research Institute, University of Helsinki, Helsinki, Finland. [15] Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. [16] The Francis Crick Institute, London, UK. [17] Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi. [18] Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi. [19] Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden. pekka.katajisto@helsinki.fi. [20] Cancer Research UK Beatson Institute, Glasgow, UK. o.sansom@beatson.gla.ac.uk. [21] SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA. o.sansom@beatson.gla.ac.uk. [22] Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. o.sansom@beatson.gla.ac.uk. [23]
DOI 10.1038/s41586-021-03525-z
PMID 34079124
发布时间 2024-03-10
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