Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.

导出原文传递

翻译打印收藏纠错

作者： Matthew W D,Perry ^[1] ; Karin,Björhall ^[2] ; Peter,Bold ^[3] ; Mikael,Brűlls ^[4] ; Ulf,Börjesson ^[5] ; Johan,Carlsson ^[6] ; Hui-Fang Amy,Chang ^[1] ; Yunhua,Chen ^[7] ; Anders,Eriksson ^[1] ; Britt-Marie,Fihn ^[3] ; Rebecca,Fransson ^[8] ; Linda,Fredlund ^[6] ; Hongbin,Ge ^[7] ; Haijuan,Huang ^[7] ; Kostas,Karabelas ^[9] ; Eva,Lamm Bergström ^[3] ; Sarah,Lever ^[1] ; Helena,Lindmark ^[6] ; Mickael,Mogemark ^[1] ; Antonios,Nikitidis ^[1] ; Anna-Pia,Palmgren ^[1] ; Nils,Pemberton ^[1] ; Jens,Petersen ^[10] ; Mio,Rodrigo Blomqvist ^[11] ; Reed W,Smith ^[1] ; Matthew J,Thomas ^[2] ; Victoria,Ullah ^[1] ; Christian,Tyrchan ^[1] ; Tiiu,Wennberg ^[2] ; Annika,Westin Eriksson ^[12] ; Wenzhen,Yang ^[7] ; Shuchun,Zhao ^[7] ; Linda,Öster ^[10]

作者单位： Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[1] Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[2] DMPK, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[3] Early Product Development & Manufacturing, Pharmaceutical Sciences R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[4] Computational Chemistry, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[5] Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[6] Pharmaron Beijing Co., Ltd., No. 6 Taihe Road, BDA, Beijing 100176, P.R. China. ^[7] Advanced Drug Delivery, Pharmaceutical Sciences R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[8] Projects, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[9] Structure & Biophysics, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[10] Bioscience Cough and In Vivo, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[11] Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden. ^[12]