Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma.

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作者： Shuai,Wu ^[1] ; Takeshi,Fukumoto ^[1] ; Jianhuang,Lin ^[1] ; Timothy,Nacarelli ^[1] ; Yemin,Wang ^[2] ; Dionzie,Ong ^[3] ; Heng,Liu ^[2] ; Nail,Fatkhutdinov ^[1] ; Joseph A,Zundell ^[1] ; Sergey,Karakashev ^[1] ; Wei,Zhou ^[1] ; Lauren E,Schwartz ^[1] ; Hsin-Yao,Tang ^[4] ; Ronny,Drapkin ^[5] ; Qin,Liu ^[6] ; David G,Huntsman ^[7] ; Andrew V,Kossenkov ^[2] ; David W,Speicher ^[1] ; Zachary T,Schug ^[5] ; Chi,Van Dang ^[7] ; Rugang,Zhang ^[7]

作者单位： Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, PA, USA. ^[1] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. ^[2] Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada. ^[3] Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[4] Proteomics and Metabolomics Facility, The Wistar Institute, Philadelphia, PA, USA. ^[5] Department of Obstetrics and Gynecology, Penn Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA. ^[6] Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA. ^[7] Ludwig Institute for Cancer Research, New York, NY, USA. ^[8] Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, PA, USA. rzhang@wistar.org. ^[9]

主题词腺癌, 透明细胞(Adenocarcinoma, Clear Cell);动物(Animals);DNA结合蛋白质类(DNA-Binding Proteins);女(雌)性(Female);谷氨酰胺酶(Glutaminase);谷氨酰胺(Glutamine);人类(Humans);小鼠(Mice);核蛋白质类(Nuclear Proteins);卵巢肿瘤(Ovarian Neoplasms);转录因子(Transcription Factors)

DOI 10.1038/s43018-020-00160-x

PMID 34085048

发布时间 2023-02-11

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Nature cancer

2021年2卷2期

189-200页

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Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma.

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Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma.

Nature cancer

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Nature cancer

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