Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1<sub>157-165</sub> tumor-specific peptide.

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作者： Eugene,Shenderov ^[1] ; Matheswaran,Kandasamy ^[2] ; Uzi,Gileadi ^[3] ; Jili,Chen ^[4] ; Dawn,Shepherd ^[4] ; James,Gibbs ^[4] ; Gennaro,Prota ^[4] ; Jonathan D,Silk ^[2] ; Jonathan W,Yewdell ^[4] ; Vincenzo,Cerundolo ^[4]

作者单位： MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UK Eugene.Shenderov@jhmi.edu. ^[1] National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[2] Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA. ^[3] MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, UK. ^[4] Next Generation Research, Adaptimmune, Abingdon, UK. ^[5]

关键词 CD8-Positive T-Lymphocytes adoptive cellular immunity immunotherapy

主题词动物(Animals);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);癌症疫苗(Cancer Vaccines);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);HLA-A2抗原(HLA-A2 Antigen);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);肿瘤蛋白质类(Neoplasm Proteins);肽碎片(Peptide Fragments);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);胸腺瘤(Thymoma);胸腺肿瘤(Thymus Neoplasms);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1136/jitc-2021-002544

PMID 34088742

发布时间 2021-12-20

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Journal for immunotherapy of cancer

2021年9卷6期

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Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1<sub>157-165</sub> tumor-specific peptide.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1<sub>157-165</sub> tumor-specific peptide.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

相关期刊

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