换一批
第一作者：
Itziar,de Rojas
第一单位：
Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.;CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
作者：
Itziar,de Rojas [1]
;
Sonia,Moreno-Grau [1]
;
Niccolo,Tesi [2]
;
Benjamin,Grenier-Boley [3]
;
Victor,Andrade [4]
;
Iris E,Jansen [5]
;
Nancy L,Pedersen [6]
;
Najada,Stringa [7]
;
Anna,Zettergren [8]
;
Isabel,Hernández [1]
;
Laura,Montrreal [9]
;
Carmen,Antúnez [10]
;
Anna,Antonell [11]
;
Rick M,Tankard [12]
;
Joshua C,Bis [13]
;
Rebecca,Sims [14]
;
Céline,Bellenguez [3]
;
Inés,Quintela [15]
;
Antonio,González-Perez [16]
;
Miguel,Calero [17]
;
Emilio,Franco-Macías [18]
;
Juan,Macías [19]
;
Rafael,Blesa [20]
;
Laura,Cervera-Carles [20]
;
Manuel,Menéndez-González [21]
;
Ana,Frank-García [22]
;
Jose Luís,Royo [23]
;
Fermin,Moreno [24]
;
Raquel,Huerto Vilas [25]
;
Miquel,Baquero [26]
;
Mónica,Diez-Fairen [27]
;
Carmen,Lage [28]
;
Sebastián,García-Madrona [29]
;
Pablo,García-González [9]
;
Emilio,Alarcón-Martín [30]
;
Sergi,Valero [1]
;
Oscar,Sotolongo-Grau [9]
;
Abbe,Ullgren [31]
;
Adam C,Naj [32]
;
Afina W,Lemstra [33]
;
Alba,Benaque [9]
;
Alba,Pérez-Cordón [9]
;
Alberto,Benussi [34]
;
Alberto,Rábano [35]
;
Alessandro,Padovani [34]
;
Alessio,Squassina [36]
;
Alexandre,de Mendonça [37]
;
Alfonso,Arias Pastor [25]
;
Almar A L,Kok [38]
;
Alun,Meggy [39]
;
Ana Belén,Pastor [40]
;
Ana,Espinosa [1]
;
Anaïs,Corma-Gómez [19]
;
Angel,Martín Montes [41]
;
Ángela,Sanabria [1]
;
Anita L,DeStefano [42]
;
Anja,Schneider [43]
;
Annakaisa,Haapasalo [44]
;
Anne,Kinhult Ståhlbom [31]
;
Anne,Tybjærg-Hansen [45]
;
Annette M,Hartmann [46]
;
Annika,Spottke [47]
;
Arturo,Corbatón-Anchuelo [48]
;
Arvid,Rongve [49]
;
Barbara,Borroni [34]
;
Beatrice,Arosio [50]
;
Benedetta,Nacmias [51]
;
Børge G,Nordestgaard [52]
;
Brian W,Kunkle [53]
;
Camille,Charbonnier [54]
;
Carla,Abdelnour [1]
;
Carlo,Masullo [55]
;
Carmen,Martínez Rodríguez [56]
;
Carmen,Muñoz-Fernandez [57]
;
Carole,Dufouil [58]
;
Caroline,Graff [31]
;
Catarina B,Ferreira [59]
;
Caterina,Chillotti [60]
;
Chandra A,Reynolds [61]
;
Chiara,Fenoglio [62]
;
Christine,Van Broeckhoven [63]
;
Christopher,Clark [64]
;
Claudia,Pisanu [36]
;
Claudia L,Satizabal [65]
;
Clive,Holmes [66]
;
Dolores,Buiza-Rueda [67]
;
Dag,Aarsland [68]
;
Dan,Rujescu [46]
;
Daniel,Alcolea [20]
;
Daniela,Galimberti [69]
;
David,Wallon [70]
;
Davide,Seripa [71]
;
Edna,Grünblatt [72]
;
Efthimios,Dardiotis [73]
;
Emrah,Düzel [74]
;
Elio,Scarpini [69]
;
Elisa,Conti [75]
;
Elisa,Rubino [76]
;
Ellen,Gelpi [77]
;
Eloy,Rodriguez-Rodriguez [28]
;
Emmanuelle,Duron [78]
;
Eric,Boerwinkle [79]
;
Evelyn,Ferri [80]
;
Fabrizio,Tagliavini [81]
;
Fahri,Küçükali [63]
;
Florence,Pasquier [82]
;
Florentino,Sanchez-Garcia [83]
;
Francesca,Mangialasche [84]
;
Frank,Jessen [85]
;
Gaël,Nicolas [86]
;
Geir,Selbæk [87]
;
Gemma,Ortega [1]
;
Geneviève,Chêne [58]
;
Georgios,Hadjigeorgiou [88]
;
Giacomina,Rossi [81]
;
Gianfranco,Spalletta [89]
;
Giorgio,Giaccone [81]
;
Giulia,Grande [90]
;
Giuliano,Binetti [91]
;
Goran,Papenberg [90]
;
Harald,Hampel [92]
;
Henri,Bailly [93]
;
Henrik,Zetterberg [94]
;
Hilkka,Soininen [95]
;
Ida K,Karlsson [96]
;
Ignacio,Alvarez [27]
;
Ildebrando,Appollonio [97]
;
Ina,Giegling [46]
;
Ingmar,Skoog [8]
;
Ingvild,Saltvedt [98]
;
Innocenzo,Rainero [99]
;
Irene,Rosas Allende [100]
;
Jakub,Hort [101]
;
Janine,Diehl-Schmid [102]
;
Jasper,Van Dongen [103]
;
Jean-Sebastien,Vidal [93]
;
Jenni,Lehtisalo [104]
;
Jens,Wiltfang [105]
;
Jesper Qvist,Thomassen [106]
;
Johannes,Kornhuber [107]
;
Jonathan L,Haines [108]
;
Jonathan,Vogelgsang [109]
;
Juan A,Pineda [19]
;
Juan,Fortea [20]
;
Julius,Popp [110]
;
Jürgen,Deckert [111]
;
Katharina,Buerger [112]
;
Kevin,Morgan [113]
;
Klaus,Fließbach [114]
;
Kristel,Sleegers [63]
;
Laura,Molina-Porcel [115]
;
Lena,Kilander [116]
;
Leonie,Weinhold [117]
;
Lindsay A,Farrer [118]
;
Li-San,Wang [119]
;
Luca,Kleineidam [4]
;
Lucia,Farotti [120]
;
Lucilla,Parnetti [120]
;
Lucio,Tremolizzo [97]
;
Lucrezia,Hausner [121]
;
Luisa,Benussi [122]
;
Lutz,Froelich [121]
;
M Arfan,Ikram [123]
;
M Candida,Deniz-Naranjo [83]
;
Magda,Tsolaki [124]
;
Maitée,Rosende-Roca [1]
;
Malin,Löwenmark [116]
;
Marc,Hulsman [125]
;
Marco,Spallazzi [126]
;
Margaret A,Pericak-Vance [127]
;
Margaret,Esiri [128]
;
María,Bernal Sánchez-Arjona [18]
;
Maria Carolina,Dalmasso [129]
;
María Teresa,Martínez-Larrad [48]
;
Marina,Arcaro [130]
;
Markus M,Nöthen [131]
;
Marta,Fernández-Fuertes [19]
;
Martin,Dichgans [132]
;
Martin,Ingelsson [116]
;
Martin J,Herrmann [111]
;
Martin,Scherer [133]
;
Martin,Vyhnalek [101]
;
Mary H,Kosmidis [134]
;
Mary,Yannakoulia [135]
;
Matthias,Schmid [136]
;
Michael,Ewers [112]
;
Michael T,Heneka [43]
;
Michael,Wagner [43]
;
Michela,Scamosci [137]
;
Miia,Kivipelto [138]
;
Mikko,Hiltunen [139]
;
Miren,Zulaica [140]
;
Montserrat,Alegret [1]
;
Myriam,Fornage [141]
;
Natalia,Roberto [9]
;
Natasja M,van Schoor [7]
;
Nazib M,Seidu [8]
;
Nerisa,Banaj [142]
;
Nicola J,Armstrong [12]
;
Nikolaos,Scarmeas [143]
;
Norbert,Scherbaum [144]
;
Oliver,Goldhardt [102]
;
Oliver,Hanon [93]
;
Oliver,Peters [145]
;
Olivia Anna,Skrobot [146]
;
Olivier,Quenez [54]
;
Ondrej,Lerch [101]
;
Paola,Bossù [147]
;
Paolo,Caffarra [148]
;
Paolo,Dionigi Rossi [80]
;
Paraskevi,Sakka [149]
;
Patrizia,Mecocci [137]
;
Per,Hoffmann [150]
;
Peter A,Holmans [14]
;
Peter,Fischer [151]
;
Peter,Riederer [152]
;
Qiong,Yang [153]
;
Rachel,Marshall [14]
;
Rajesh N,Kalaria [154]
;
Richard,Mayeux [155]
;
Rik,Vandenberghe [156]
;
Roberta,Cecchetti [137]
;
Roberta,Ghidoni [122]
;
Ruth,Frikke-Schmidt [45]
;
Sandro,Sorbi [51]
;
Sara,Hägg [6]
;
Sebastiaan,Engelborghs [157]
;
Seppo,Helisalmi [158]
;
Sigrid,Botne Sando [159]
;
Silke,Kern [8]
;
Silvana,Archetti [160]
;
Silvia,Boschi [99]
;
Silvia,Fostinelli [122]
;
Silvia,Gil [9]
;
Silvia,Mendoza [161]
;
Simon,Mead [162]
;
Simona,Ciccone [80]
;
Srdjan,Djurovic [163]
;
Stefanie,Heilmann-Heimbach [131]
;
Steffi,Riedel-Heller [164]
;
Teemu,Kuulasmaa [139]
;
Teodoro,Del Ser [165]
;
Thibaud,Lebouvier [82]
;
Thomas,Polak [111]
;
Tiia,Ngandu [166]
;
Timo,Grimmer [102]
;
Valentina,Bessi [167]
;
Valentina,Escott-Price [168]
;
Vilmantas,Giedraitis [116]
;
Vincent,Deramecourt [82]
;
Wolfgang,Maier [43]
;
Xueqiu,Jian [169]
;
Yolande A L,Pijnenburg [33]
;
EADB contributors [146]
;
GR@ACE study group [29]
;
DEGESCO consortium [28]
;
IGAP (ADGC, CHARGE, EADI, GERAD) [27]
;
PGC-ALZ consortia [170]
;
Patrick Gavin,Kehoe [25]
;
Guillermo,Garcia-Ribas [171]
;
Pascual,Sánchez-Juan [172]
;
Pau,Pastor [173]
;
Jordi,Pérez-Tur [100]
;
Gerard,Piñol-Ripoll [20]
;
Adolfo,Lopez de Munain [174]
;
Jose María,García-Alberca [67]
;
María J,Bullido [175]
;
Victoria,Álvarez [33]
;
Alberto,Lleó [125]
;
Luis M,Real [1]
;
Pablo,Mir [16]
;
Miguel,Medina [176]
;
Philip,Scheltens [3]
;
Henne,Holstege [119]
;
Marta,Marquié [177]
;
María Eugenia,Sáez [178]
;
Ángel,Carracedo [179]
;
Philippe,Amouyel [180]
;
Gerard D,Schellenberg [11]
;
Julie,Williams [48]
;
Sudha,Seshadri [1]
;
Cornelia M,van Duijn [1]
;
Karen A,Mather [181]
;
Raquel,Sánchez-Valle [182]
;
Manuel,Serrano-Ríos [183]
;
Adelina,Orellana [184]
;
Lluís,Tárraga [20]
;
Kaj,Blennow [1]
;
Martijn,Huisman [33]
;
Ole A,Andreassen [185]
;
Danielle,Posthuma [3]
;
Jordi,Clarimón [186]
;
Mercè,Boada [187]
;
Wiesje M,van der Flier ;
Alfredo,Ramirez ;
Jean-Charles,Lambert ;
Sven J,van der Lee ;
Agustín,Ruiz
作者单位：
Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.;CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
[1]
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.;Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.;Delft Bioinformatics Lab, Delft Univeristy of Technology, Delft, The Netherlands.
[2]
Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
[3]
Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.;Department of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn, Bonn, Germany.
[4]
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.;Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands.
[5]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
[6]
Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
[7]
Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg, Gothenburg, Sweden.
[8]
Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
[9]
Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
[10]
Alzheimer's disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
[11]
Mathematics and Statistics, Murdoch University, Perth, WA, Australia.
[12]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
[13]
Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
[14]
Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
[15]
CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.
[16]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;UFIEC, Instituto de Salud Carlos III, Madrid, Spain.;CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
[17]
Unidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
[18]
Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
[19]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
[20]
Servicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, Spain.;Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.;Departamento de Medicina, Universidad de Oviedo, Oviedo, Spain.
[21]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Department of Neurology, La Paz University Hospital, Instituto de Investigación Sanitaria del Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.;Hospital La Paz Institute for Health Research, IdiPAZ, Madrid, Spain.;Universidad Autónoma de Madrid, Madrid, Spain.
[22]
Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain.
[23]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Department of Neurology, Hospital Universitario Donostia, San Sebastian, Spain.;Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain.
[24]
Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.;Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain.
[25]
Servei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
[26]
Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain.;Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain.
[27]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
[28]
Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.
[29]
Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.;Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain.
[30]
Karolinska Institutet, Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Stockholm, Sweden.;Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital-Solna, Stockholm, Sweden.
[31]
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[32]
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
[33]
Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
[34]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.;BT-CIEN, Madrid, Spain.
[35]
Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
[36]
Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
[37]
Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.;Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
[38]
UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.
[39]
CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.;BT-CIEN, Madrid, Spain.
[40]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Hospital La Paz Institute for Health Research, IdiPAZ, Madrid, Spain.;Department of Neurology, La Paz University Hospital, Madrid, Spain.
[41]
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[42]
Department of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn, Bonn, Germany.;German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
[43]
A.I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
[44]
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[45]
Martin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale), Germany.
[46]
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Department of Neurology, University of Bonn, Bonn, Germany.
[47]
Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), Madrid, Spain.;Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.
[48]
Haugesund Hospital, Helse Fonna, Department of Research and Innovation, Haugesund, Norway.;University of Bergen, Institute of Clinical Medicine (K1), Bergen, Norway.
[49]
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.;Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
[50]
Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.;IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
[51]
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;Department of Clinical Biochemistry, Herlev Gentofte Hospital, Herlev, Denmark.
[52]
Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.;John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
[53]
Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and CNR-MAJ, FHU G4 Génomique, F-76000 Rouen, France.
[54]
Institute of Neurology, Catholic University of the Sacred Heart, School of Medicine, Milan, Italy.
[55]
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.;Hospital de Cabueñes, Gijón, Spain.
[56]
Servicio de Neurología, Hospital Universitario de Gran Canaria Dr.Negrín, Las Palmas, Spain.
[57]
Inserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, CIC 1401-EC, Univ Bordeaux, Bordeaux, France.;CHU de Bordeaux, Pole de Santé Publique, Bordeaux, France.
[58]
Instituto de Medicina Molecular João lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
[59]
Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy.
[60]
Department of Psychology, University of California-Riverside, Riverside, CA, USA.
[61]
University of Milan, Dino Ferrari Center, Milan, Italy.
[62]
VIB Center for Molecular Neurology, Antwerp, Belgium.;Laboratory of Neurogenetics, Institute Born-Bunge, Antwerp, Belgium.;Department of Biomedical Sciences, University of Antwerp., Antwerp, Belgium.
[63]
Insititute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
[64]
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.;Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX, USA.
[65]
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
[66]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
[67]
Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.;Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
[68]
University of Milan, Dino Ferrari Center, Milan, Italy.;Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.
[69]
Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Neurology and CNR-MAJ, FHU G4 Génomique, F-76000 Rouen, France.
[70]
Complex Structure of Geriatrics, Department of Medical Sciences Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
[71]
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich (PUK), University of Zurich, Zurich, Switzerland.;Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.;Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
[72]
School of Medicine, University of Thessaly, Larissa, Greece.
[73]
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.;Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany.
[74]
School of Medicine and Surgery, University of Milano-Bicocca and Milan Center for Neuroscience, Milan, Italy.
[75]
Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy.
[76]
Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.;Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.
[77]
APHP, Hôpital Brousse, equipe INSERM 1178, MOODS, Villejuif, France.;Université Paris-Saclay, UVSQ, Inserm, CESP, Team MOODS, Le Kremlin-Bicêtre, Paris, France.;APHP, Hôpital Broca, Paris, France.
[78]
School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.;Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
[79]
Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
[80]
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
[81]
Inserm U1172, CHU, DISTAlz, LiCEND, Univ Lille, Lille, France.;CHU CNR-MAJ, Lille, France.
[82]
Servicio de Inmunología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
[83]
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
[84]
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.;Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
[85]
Hospital de Cabueñes, Gijón, Spain.
[86]
Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.;Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.;Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
[87]
Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
[88]
Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.;Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
[89]
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
[90]
MAC-Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.;Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
[91]
Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
[92]
APHP, Hôpital Broca, Paris, France.;EA 4468, Sorbonne Paris Cité, Université Paris Descartes, Paris, France.
[93]
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.;Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.;Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.;UK Dementia Research Institute at UCL, London, UK.
[94]
Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland.;Neurocenter, neurology, Kuopio University Hospital, Kuopio, Finland.
[95]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.;Institute for Gerontology and Aging Research Network-Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.
[96]
School of Medicine and Surgery, University of Milano-Bicocca and Milan Center for Neuroscience, Milan, Italy.;Neurology Unit, 'San Gerardo' hospital, Monza, Italy.
[97]
Department of Geriatrics, Clinic of Medicine, St Olavs Hospital, University Hospital of Trondheim, Trondheim, Norway.;Department of Neuromedicine and Movement Science, Norwegian University of Science and Technhology (NTNU), Trondheim, Norway.
[98]
Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
[99]
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.;Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.
[100]
Memory Clinic, Department of Neurology, 2nd Faculty of Medicine and Motol University Hospital, Charles University, Prague, Czech Republic.;International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
[101]
Department of Psychiatry and Psychotherapy, School of Medicine Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
[102]
VIB Center for Molecular Neurology, Antwerp, Belgium.;Laboratory of Neurogenetics, Institute Born-Bunge, Antwerp, Belgium.
[103]
Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland.;Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
[104]
Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.;German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.;Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
[105]
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
[106]
Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
[107]
Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.;Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
[108]
Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.;Translational Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
[109]
Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland.;University of Zürich, Zürich, Switzerland.;Old age Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
[110]
Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
[111]
Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
[112]
Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.
[113]
Department of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn, Bonn, Germany.
[114]
Alzheimer's disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.;Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
[115]
Department of Public Health and Caring Sciences/Geriatrics, Uppsala, Sweden.
[116]
Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
[117]
Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA.
[118]
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[119]
Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
[120]
Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
[121]
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
[122]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
[123]
1st Department of Neurology Aristotle University of Thessaloniki, Thessaloniki, Greece.
[124]
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.;Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
[125]
Azienda Ospedaliero-Universitaria, Parma, Italy.
[126]
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
[127]
Nuffield Department of Clinical Neurosciences, Oxford, UK.
[128]
Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
[129]
Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.
[130]
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
[131]
Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
[132]
Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
[133]
Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
[134]
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
[135]
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
[136]
Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
[137]
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.;Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.;Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.;Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden.
[138]
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
[139]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain.
[140]
Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
[141]
Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
[142]
1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.;Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Depatment of Neurology, Columbia University, New York, NY, USA.
[143]
LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
[144]
Department of Psychiatry and Psychotherapy and Experimental and Clinical Research Center (ECRC), Charité-Universitätsmedizin Berlin, Berlin, Germany.;German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
[145]
Bristol Medical School (THS), University of Bristol, Southmead Hospital, Bristol, UK.
[146]
Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
[147]
Unit of Neuroscience, DIMEC, University of Parma, Parma, Italy.
[148]
Athens Association of Alzheimer's disease and Related Disorders, Athens, Greece.
[149]
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.;Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
[150]
Department of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria.
[151]
Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
[152]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[153]
Translational and Clincial Research Institute, Newcastle University, Newcastle upon Tyne, UK.;Campus for Ageing anf Vitality, Newcastle upon Tyne, UK.
[154]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.;Department of Neurology, Columbia University, New York, NY, USA.
[155]
Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium.;Neurology Department, University Hospitals Leuven, Leuven, Belgium.
[156]
Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.;Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.;Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.;Department of Neurology, VUB University Hospital Brussels (UZ Brussel), Brussels, Belgium.
[157]
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
[158]
Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.;Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
[159]
Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy.
[160]
Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain.
[161]
MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
[162]
Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.;NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.
[163]
Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
[164]
Department of Neurology/CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
[165]
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.;Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
[166]
Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.;Azienda Ospedaliero-Universitaria Careggi Largo Brambilla, Florence, Italy.
[167]
Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.;UKDRI Cardiff, Cardiff University, Cardiff, UK.
[168]
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.
[169]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Unitat de Genètica Molecular, Institut de Biomedicina de València-CSIC, Valencia, Spain.;Unidad Mixta de Neurologia Genètica, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
[170]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Department of Neurology, Hospital Universitario Donostia, San Sebastian, Spain.;Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain.;Department of Neurosciences, Faculty of Medicine and Nursery, University of the Basque Country, San Sebastián, Spain.
[171]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain.
[172]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Universidad Autónoma de Madrid, Madrid, Spain.;Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain.;Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.
[173]
Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.;Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina, Universidad de Málaga, Málaga, Spain.
[174]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
[175]
Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.;Fundación Pública Galega de Medicina Xenómica-CIBERER-IDIS, Santiago de Compostela, Spain.
[176]
Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.;UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.
[177]
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.;Framingham Heart Study, Framingham, MA, USA.
[178]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.;Nuffield Department of Population Health, University of Oxford, Oxford, UK.
[179]
Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.;Neuroscience Research Australia, Sydney, NSW, Australia.
[180]
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.;Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
[181]
Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.;Department of Sociology, VU University, Amsterdam, The Netherlands.
[182]
NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.;Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
[183]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands.
[184]
Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.;Department of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn, Bonn, Germany.;German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Department of Psychiatry, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.
[185]
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl.;Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl.
[186]
Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain. aruiz@fundacioace.org.;CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain. aruiz@fundacioace.org.
[187]
医学主题词
发病年龄(Age of Onset);老年人(Aged);老年人, 80以上(Aged, 80 and over);阿尔茨海默病(Alzheimer Disease);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);载脂蛋白E类(Apolipoproteins E);病例对照研究(Case-Control Studies);队列研究(Cohort Studies);女(雌)性(Female);随访研究(Follow-Up Studies);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);杂合子(Heterozygote);人类(Humans);男(雄)性(Male);中年人(Middle Aged);多因子遗传(Multifactorial Inheritance);多态性, 单核苷酸(Polymorphism, Single Nucleotide);危险性评估(Risk Assessment);危险因素(Risk Factors)
DOI
10.1038/s41467-021-22491-8
PMID
34099642
发布时间
2024-09-23
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