Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease*.

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作者： Sha,Zhu ^[1] ; Yerri,Jagadeesh ^[2] ; Anh Tuan,Tran ^[1] ; Shuki,Imaeda ^[3] ; Alisdair,Boraston ^[4] ; Dominic S,Alonzi ^[5] ; Ana,Poveda ^[6] ; Yongmin,Zhang ^[1] ; Jérôme,Désiré ^[2] ; Julie,Charollais-Thoenig ^[7] ; Stéphane,Demotz ^[7] ; Atsushi,Kato ^[3] ; Terry D,Butters ^[5] ; Jesús,Jiménez-Barbero ^[6] ; Matthieu,Sollogoub ^[1] ; Yves,Blériot ^[2]

作者单位： Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 place Jussieu, 75005, Paris, France. ^[1] Glycochemistry Group of "OrgaSynth" Team, IC2MP, UMR-CNRS 7285, Université de Poitiers, 4 rue Michel Brunet, 86073, Poitiers Cedex 9, France. ^[2] Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. ^[3] Department of Biochemistry and Microbiology, University of Victoria, P.O. Box 3055, Station CSC V8W 3P6, Victoria, BC, Canada. ^[4] Oxford Glycobiology Institute, University of Oxford, South Parks Road, Oxford, OX1 3QU, U.K. ^[5] CIC bioGUNE, Bizkaia Technological Park, Building 801A-1°, 48160, Derio-Bizkaia, Spain. ^[6] Dorphan SA, EPFL Innovation Park, 1015, Lausanne, Switzerland. ^[7]

关键词 X-ray crystallography glycosidase iminosugars pharmacological chaperones

主题词乙酰氨基葡糖苷酶(Acetylglucosaminidase);糖苷类(Glycosides);人类(Humans);黏多糖累积病Ⅲ型(Mucopolysaccharidosis III);少见病(Rare Diseases)

DOI 10.1002/chem.202101408

PMID 34106504

发布时间 2021-08-09

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