Structural analysis of the full-length human LRRK2.

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第一作者： Alexander,Myasnikov

第一单位： Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Cryo-EM and Tomography Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

作者： Alexander,Myasnikov ^[1] ; Hanwen,Zhu ^[2] ; Patricia,Hixson ^[2] ; Boer,Xie ^[3] ; Kaiwen,Yu ^[4] ; Aaron,Pitre ^[5] ; Junmin,Peng ^[6] ; Ji,Sun ^[7]

作者单位： Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Cryo-EM and Tomography Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[1] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[2] Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[3] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[4] Cell & Tissue Imaging Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[5] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[6] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: ji.sun@stjude.org. ^[7]

关键词 LRRK2 LRRK2 dimer LRRK2 mutations Parkinson's disease kinase

主题词氨基酸序列(Amino Acid Sequence);HEK293细胞(HEK293 Cells);人类(Humans);模型, 分子(Models, Molecular);蛋白质多聚化(Protein Multimerization);蛋白质结构, 二级(Protein Structure, Secondary)

DOI 10.1016/j.cell.2021.05.004

PMID 34107286

发布时间 2022-09-29

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