Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice.

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作者： David B,Stagg ^[1] ; Jacob R,Gillingham ^[2] ; Alisa B,Nelson ^[3] ; Justin E,Lengfeld ^[2] ; D André,d'Avignon ^[2] ; Patrycja,Puchalska ^[2] ; Peter A,Crawford ^[4]

作者单位： Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. ^[1] Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA. ^[2] Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA. ^[3] Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA. Electronic address: crawforp@umn.edu. ^[4]

关键词 Glucose metabolism Hepatic ketogenesis Liver oxidative metabolism Metabolic flux Metabolomics Mitochondrial redox homeostasis

主题词动物(Animals);柠檬酸循环(Citric Acid Cycle);女(雌)性(Female);葡萄糖(Glucose);肝细胞(Hepatocytes);羟丁酸脱氢酶(Hydroxybutyrate Dehydrogenase);酮类(Ketones);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout)

DOI 10.1016/j.molmet.2021.101269

PMID 34116232

发布时间 2022-03-24

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Molecular metabolism

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Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice.

Molecular metabolism

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Molecular metabolism

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Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice.

Molecular metabolism

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Molecular metabolism

相关期刊

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