Chemoenzymatic Synthesis of Complex N-Glycans of the Parasite S. mansoni to Examine the Importance of Epitope Presentation on DC-SIGN recognition.

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作者： Apoorva D,Srivastava ^[1] ; Luca,Unione ^[1] ; Mehman,Bunyatov ^[1] ; Ivan A,Gagarinov ^[1] ; Sandra,Delgado ^[2] ; Nicola G A,Abrescia ^[2] ; Ana,Ardá ^[3] ; Geert-Jan,Boons ^[2]

作者单位： Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Bijvoet Center for Biomolecular Research, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands. ^[1] Molecular Recognition and Host-Pathogen Interactions, CIC bioGUNE, Basque Research and Technology Alliance, BRTA, Bizkaia Technology Park, Building 800, 48162, Derio, Bizkaia, Spain. ^[2] Ikerbasque, Basque Foundation for Science, 48013, Bilbao, Bizkaia, Spain. ^[3] Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA, 30602, USA. ^[4] Department of Chemistry, University of Georgia, Athens, GA, 30602, USA. ^[5]

关键词 NMR chemoenzymatic synthesis cryo-EM glycan glycosyl transferase

主题词动物(Animals);表位(Epitopes);人类(Humans);外源凝集素类(Lectins);多糖类(Polysaccharides);曼森血吸虫(Schistosoma mansoni)

DOI 10.1002/anie.202105647

PMID 34124805

发布时间 2021-11-03

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准确一般字义偏差语意偏离译文作用小提交