Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients.

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第一作者： Yang,Chen

第一单位： Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.

作者： Yang,Chen ^[1] ; Yanyan,Li ^[1] ; Changsong,Qi ^[1] ; Cheng,Zhang ^[1] ; Dan,Liu ^[1] ; Youping,Deng ^[2] ; Yuanyuan,Fu ^[2] ; Vedbar S,Khadka ^[2] ; Daisy Dandan,Wang ^[3] ; Shanyang,Tan ^[4] ; Shujun,Liu ^[4] ; Zhi,Peng ^[1] ; Jifang,Gong ^[1] ; Peter Ping,Lin ^[3] ; Xiaotian,Zhang ^[1] ; Jian,Li ^[1] ; Yilin,Li ^[5] ; Lin,Shen ^[6]

作者单位： Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. ^[1] Bioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA. ^[2] Cytelligen, San Diego, CA, USA. ^[3] Jiangsu Cowin Biotech Co., Ltd, China Medical City, Taizhou, Jiangsu, China. ^[4] Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. Electronic address: liyilin@bjcancer.org. ^[5] Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. Electronic address: shenlin@bjmu.edu.cn. ^[6]

关键词 Circulating tumor cells Gastric cancer Single-cell DNA sequencing Size heterogeneity Therapeutic resistance