Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.

导出 OA

翻译打印收藏纠错

作者： Yuki,Nishida ^[1] ; Ran,Zhao ^[1] ; Lauren E,Heese ^[1] ; Hiroki,Akiyama ^[1] ; Shreya,Patel ^[1] ; Alex M,Jaeger ^[2] ; Rodrigo O,Jacamo ^[1] ; Kensuke,Kojima ^[1] ; Man Chun John,Ma ^[3] ; Vivian R,Ruvolo ^[4] ; Dhruv,Chachad ^[1] ; William,Devine ^[1] ; Susan,Lindquist ^[5] ; R Eric,Davis ^[2] ; John A,Porco ^[4] ; Luke,Whitesell ^[5] ; Michael,Andreeff ^[2] ; Jo,Ishizawa ^[6]

作者单位： Department of Leukemia, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[1] Whitehead Institute for Biomedical Research, Cambridge, MA, USA. ^[2] Department of Hematology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan. ^[3] Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[4] Department of Chemistry, Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA. ^[5] Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. ^[6] Department of Leukemia, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. mandreef@mdanderson.org. ^[7] Department of Leukemia, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jishizawa@mdanderson.org. ^[8]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);真核细胞起始因子4A(Eukaryotic Initiation Factor-4A);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);分子靶向治疗(Molecular Targeted Therapy)

DOI 10.1038/s41375-021-01308-z

PMID 34127794

发布时间 2023-01-30

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交