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High-dimensional mass cytometry identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria.

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第一作者： Lisa J,Ioannidis

第一单位： Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.;Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.

作者： Lisa J,Ioannidis ^[1] ; Halina M,Pietrzak ^[1] ; Ann,Ly ^[1] ; Retno As,Utami ^[2] ; Emily M,Eriksson ^[1] ; Stephanie I,Studniberg ^[1] ; Waruni,Abeysekera ^[1] ; Connie Sn,Li-Wai-Suen ^[1] ; Dylan,Sheerin ^[1] ; Julie,Healer ^[1] ; Agatha M,Puspitasari ^[3] ; Dwi,Apriyanti ^[3] ; Farah N,Coutrier ^[3] ; Jeanne R,Poespoprodjo ^[4] ; Enny,Kenangalem ^[4] ; Benediktus,Andries ^[4] ; Pak,Prayoga ^[4] ; Novita,Sariyanti ^[4] ; Gordon K,Smyth ^[5] ; Leily,Trianty ^[3] ; Alan F,Cowman ^[1] ; Ric N,Price ^[6] ; Rintis,Noviyanti ^[3] ; Diana S,Hansen ^[1]

作者单位： Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.;Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia. ^[1] Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.;Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.;Eijkman Institute for Molecular Biology, Jakarta, Indonesia. ^[2] Eijkman Institute for Molecular Biology, Jakarta, Indonesia. ^[3] Papuan Health and Community Development Foundation, Papua, Indonesia. ^[4] Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.;School of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria, Australia. ^[5] Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia.;Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.;Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand. ^[6]

关键词 Adaptive immunity Immunology Infectious disease Malaria

医学主题词抗疟药(Antimalarials);无症状感染(Asymptomatic Infections);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);横断面研究(Cross-Sectional Studies);人类(Humans);免疫, 细胞(Immunity, Cellular);免疫表型分型(Immunophenotyping);印度尼西亚(Indonesia);疟疾, 间日(Malaria, Vivax);间日疟原虫(Plasmodium vivax)

DOI 10.1172/jci.insight.148086

PMID 34128836

发布时间 2025-05-30

基金项目

WT_/Wellcome Trust/United Kingdom 200909/Z/16/Z/WT_/Wellcome Trust/United Kingdom

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High-dimensional mass cytometry identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria.

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High-dimensional mass cytometry identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria.

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