Mn<sup>2+</sup> coordinates Cap-0-RNA to align substrates for efficient 2'-<i>O</i>-methyl transfer by SARS-CoV-2 nsp16.

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第一作者： George,Minasov

第一单位： Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine,,Chicago, IL 60611, USA.;Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

作者： George,Minasov ^[1] ; Monica,Rosas-Lemus ^[1] ; Ludmilla,Shuvalova ^[1] ; Nicole L,Inniss ^[1] ; Joseph S,Brunzelle ^[2] ; Courtney M,Daczkowski ^[3] ; Paul,Hoover ^[4] ; Andrew D,Mesecar ^[5] ; Karla J F,Satchell ^[6]

作者单位： Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine,,Chicago, IL 60611, USA.;Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. ^[1] Northwestern Synchrotron Research Center, Life Sciences Collaborative Access Team, Northwestern University, Argonne, IL 60439, USA. ^[2] Department of Biochemistry and Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. ^[3] Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine,,Chicago, IL 60611, USA. ^[4] Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.;Department of Biochemistry and Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. ^[5] Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine,,Chicago, IL 60611, USA. k-satchell@northwestern.edu.;Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. ^[6]