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Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers.

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第一作者: Edurne,Rujas
第一单位: Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.;Department of Biochemistry, University of Toronto, Toronto, ON, Canada.;Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao, Spain.
作者单位: Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.;Department of Biochemistry, University of Toronto, Toronto, ON, Canada.;Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao, Spain. [1] Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada. [2] Department of Immunology, University of Toronto, Toronto, ON, Canada. [3] Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.;The Structural & Biophysical Core Facility, The Hospital for Sick Children Research Institute, Toronto, ON, Canada. [4] Combined Containment Level 3 Unit, University of Toronto, Toronto, ON, Canada.;Institute of Medical Science, University of Toronto, Toronto, ON, Canada. [5] Combined Containment Level 3 Unit, University of Toronto, Toronto, ON, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. [6] Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.;Department of Biochemistry, University of Toronto, Toronto, ON, Canada. [7] Distributed Bio, South San Francisco, CA, USA. [8] Combined Containment Level 3 Unit, University of Toronto, Toronto, ON, Canada. [9] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.;Sunnybrook Health Sciences Centre, Toronto, ON, Canada. [10] Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. [11] Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.;Department of Biochemistry, University of Toronto, Toronto, ON, Canada.;Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. [12] Department of Immunology, University of Toronto, Toronto, ON, Canada.;Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.;Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, Canada. [13] Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada. jean-philippe.julien@sickkids.ca.;Department of Biochemistry, University of Toronto, Toronto, ON, Canada. jean-philippe.julien@sickkids.ca.;Department of Immunology, University of Toronto, Toronto, ON, Canada. jean-philippe.julien@sickkids.ca. [14]
DOI 10.1038/s41467-021-23825-2
PMID 34135340
发布时间 2024-12-07
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