Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions.

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作者： Francesca,Paoletti ^[1] ; Franci,Merzel ^[1] ; Alberto,Cassetta ^[2] ; Iza,Ogris ^[1] ; Sonia,Covaceuszach ^[2] ; Jože,Grdadolnik ^[1] ; Doriano,Lamba ^[2] ; Simona,Golič Grdadolnik ^[3]

作者单位： Laboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia. ^[1] Institute of Crystallography - C.N.R.- Trieste Outstation. Area Science Park - Basovizza, S.S.14 - Km. 163.5, I-34149 Trieste, Italy. ^[2] Interuniversity Consortium "Biostructures and Biosystems National Institute", Viale delle Medaglie d'Oro 305, I-00136 Roma, Italy. ^[3]

关键词 ARIA, Ambiguous Restraints for Iterative Assignment ATP modulation BDNF, Brain Derived Neurotrophic Factor CARA, Computer Aided Resonance Assignment CS-E, Chrondroitin Sulfate E CSP, Chemical Shift Perturbation DSF, Differential Scanning Fluorimetry EI-MS, Electron Ionization Mass Spectrometry Endogenous ligands FGF2, Fibroblast Growth Factor 2 FT-IR, Fourier Transform Infrared Spectroscopy HBD, Heparin Binding Domain HSQC, Heteronuclear Single Quantum Coherence ITC, Isothermal Titration Calorimetry MALDI-TOF MS, Matrix Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry MD, Molecular Dynamics MS, Mass Spectrometry NGF interactions NGF, Nerve Growth Factor NMR, Nuclear Magnetic Resonance NOE, Nuclear Overhouser Effect NOESY, Nuclear Overhauser Effect Spectroscopy NT, NeuroTrophin Neurotrophins P20, Polysorbate 20 PME, Particle Mesh Ewald RMSD, Root Mean Square Deviation SAR, Structure-Activity Relationship SPR, Surface Plasmon Resonance STD, Saturation-Transfer Difference TrkA, Tyrosine Kinase Receptor A TrkA, p75NTR receptors p75NTR, p75 NeuroTrophin Receptor proNGF, proNGF – NGF precursor rh-proNGF, recombinant human proNGF – NGF precursor rhNGF, recombinant human NGF rmNGF, recombinant mouse NGF

DOI 10.1016/j.csbj.2021.05.009

PMID 34136093

发布时间 2021-06-19

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Computational and structural biotechnology journal

2021年19卷

2938-2949页

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Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions.

Computational and structural biotechnology journal

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Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions.

Computational and structural biotechnology journal

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Computational and structural biotechnology journal

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