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Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome.

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第一作者： Marco,Borgogno

第一单位： Molecular Modeling and Drug Discovery Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy.

作者： Marco,Borgogno ^[1] ; Annalisa,Savardi ^[2] ; Jacopo,Manigrasso ^[1] ; Alessandra,Turci ^[3] ; Corinne,Portioli ^[4] ; Giuliana,Ottonello ^[5] ; Sine Mandrup,Bertozzi ^[5] ; Andrea,Armirotti ^[5] ; Andrea,Contestabile ^[6] ; Laura,Cancedda ^[2] ; Marco,De Vivo ^[1]

作者单位： Molecular Modeling and Drug Discovery Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy. ^[1] Brain Development and Disease Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy.;Dulbecco Telethon Institute, 38123 Rome, Italy. ^[2] Brain Development and Disease Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy.;Università degli Studi di Genova, via Balbi, 5, 16126 Genoa, Italy. ^[3] Molecular Modeling and Drug Discovery Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy.;Brain Development and Disease Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy. ^[4] Analytical Chemistry Facility, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy. ^[5] Brain Development and Disease Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy. ^[6]