Massive PD-L1 and CD8 double positive TILs characterize an immunosuppressive microenvironment with high mutational burden in lung cancer.

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第一作者： Libin,Zhang

第一单位： Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.

作者： Libin,Zhang ^[1] ; Yanhui,Chen ^[2] ; Han,Wang ^[1] ; Zheyuan,Xu ^[1] ; Yang,Wang ^[1] ; Sixing,Li ^[1] ; Jun,Liu ^[1] ; Yun,Chen ^[1] ; Hongli,Luo ^[2] ; Lijia,Wu ^[3] ; Ying,Yang ^[3] ; Henghui,Zhang ^[4] ; Hao,Peng ^[5]

作者单位： Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China. ^[1] Department of Medicine, Genecast Biotechnology Co., Ltd, Wuxi, Jiangsu, China. ^[2] Department of Bioinformatics, Genecast Biotechnology Co., Ltd, Wuxi, Jiangsu, China. ^[3] Biomedical Inovation Center, Beijing Shijitan Hospital, Capital Medical University; School of Oncology, Capital Medical University, Beijing, China. ^[4] Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China phao9375@163.com. ^[5]

关键词 lung neoplasms lymphocytes tumor microenvironment tumor-infiltrating

主题词 CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);人类(Humans);免疫疗法(Immunotherapy);肺肿瘤(Lung Neoplasms);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);突变(Mutation);预后(Prognosis);肿瘤负荷(Tumor Burden);肿瘤微环境(Tumor Microenvironment)

DOI 10.1136/jitc-2021-002356

PMID 34140315

发布时间 2022-01-11

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Journal for immunotherapy of cancer

2021年9卷6期

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Massive PD-L1 and CD8 double positive TILs characterize an immunosuppressive microenvironment with high mutational burden in lung cancer.

Journal for immunotherapy of cancer

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Massive PD-L1 and CD8 double positive TILs characterize an immunosuppressive microenvironment with high mutational burden in lung cancer.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

相关期刊

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