α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity.

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作者： Jaime,Santos ^[1] ; Pablo,Gracia ^[2] ; Susanna,Navarro ^[1] ; Samuel,Peña-Díaz ^[1] ; Jordi,Pujols ^[1] ; Nunilo,Cremades ^[3] ; Irantzu,Pallarès ^[4] ; Salvador,Ventura ^[5]

作者单位： Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. ^[1] Institute for Biocomputation and Physics of Complex Systems (BIFI)-Joint Unit BIFI-IQFR (CSIC), University of Zaragoza, Zaragoza, Spain. ^[2] Institute for Biocomputation and Physics of Complex Systems (BIFI)-Joint Unit BIFI-IQFR (CSIC), University of Zaragoza, Zaragoza, Spain. ncc@unizar.es. ^[3] Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. irantzu.pallares@uab.cat. ^[4] Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. salvador.ventura@uab.es. ^[5]

主题词淀粉样蛋白(Amyloid);脑(Brain);胃肠道(Gastrointestinal Tract);人类(Humans);帕金森病(Parkinson Disease);α突触核蛋白(alpha-Synuclein)

DOI 10.1038/s41467-021-24039-2

PMID 34145261

发布时间 2023-02-03

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准确一般字义偏差语意偏离译文作用小提交