Down-regulation of TNF-α via macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis.

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第一作者： Jieun,Lee

第一单位： Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University, Seoul, Republic of Korea.

作者： Jieun,Lee ^[1] ; Wooic,Son ^[2] ; Juhyeong,Hong ^[1] ; Yoonsung,Song ^[1] ; Chul-Su,Yang ^[3] ; Yong-Hee,Kim ^[4]

作者单位： Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University, Seoul, Republic of Korea. ^[1] Department of Molecular and Life Science, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, Republic of Korea. ^[2] Department of Molecular and Life Science, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, Republic of Korea. Electronic address: chulsuyang@hanyang.ac.kr. ^[3] Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University, Seoul, Republic of Korea. Electronic address: yongheekim@hanyang.ac.kr. ^[4]

关键词 Anti-inflammatory gene therapy Combination therapy RNA interference Targeted gene carrier

主题词减量调节(Down-Regulation);人类(Humans);巨噬细胞(Macrophages);RNA干扰(RNA Interference);脓毒症(Sepsis);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1016/j.jconrel.2021.06.022

PMID 34147573

发布时间 2021-10-28

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