换一批Saikosaponins and the deglycosylated metabolites exert liver meridian guiding effect through PXR/CYP3A4 inhibition.
第一作者：
Qiwei,Liu
第一单位：
Key Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Educational, Nanjing, 210009, China; State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China.
作者：
医学主题词
柴胡属(Bupleurum);癌, 肝细胞(Carcinoma, Hepatocellular);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);剂量效应关系, 药物(Dose-Response Relationship, Drug);基因表达调控(Gene Expression Regulation);Hep G2细胞(Hep G2 Cells);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);肝肿瘤(Liver Neoplasms);经络(Meridians);微粒体, 肝(Microsomes, Liver);齐墩果酸(Oleanolic Acid);皂苷类(Saponins);时间因素(Time Factors)
DOI
10.1016/j.jep.2021.114344
PMID
34147617
发布时间
2021-12-14
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