Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex.
第一作者:
Liang,Zhang
第一单位:
Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, Key Laboratory of Reproduction Regulation of NPFPC (SIPPR, IRD), School of Life Sciences, Fudan University, 200438, Shanghai, China.
作者:
主题词
腺苷三磷酸(Adenosine Triphosphate);动物(Animals);细胞增殖(Cell Proliferation);女(雌)性(Female);糖酵解(Glycolysis);HEK293细胞(HEK293 Cells);人类(Humans);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);线粒体(Mitochondria);氧化磷酸化(Oxidative Phosphorylation);氧耗量(Oxygen Consumption);丙酮酸脱氢酶复合物(Pyruvate Dehydrogenase Complex);STAT5转录因子(STAT5 Transcription Factor);肿瘤负荷(Tumor Burden);肿瘤微环境(Tumor Microenvironment);肿瘤抑制蛋白质类(Tumor Suppressor Proteins);宫颈肿瘤(Uterine Cervical Neoplasms);小鼠(Mice)
DOI
10.1038/s41419-021-03908-0
PMID
34148062
发布时间
2024-02-26
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