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Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy.

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第一作者： Genevieve E,Martin

第一单位： Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.;Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia.

作者： Genevieve E,Martin ^[1] ; Debattama R,Sen ^[2] ; Matthew,Pace ^[3] ; Nicola,Robinson ^[3] ; Jodi,Meyerowitz ^[3] ; Emily,Adland ^[4] ; John P,Thornhill ^[5] ; Mathew,Jones ^[3] ; Ane,Ogbe ^[3] ; Lucia,Parolini ^[3] ; Natalia,Olejniczak ^[3] ; Panagiota,Zacharopoulou ^[3] ; Helen,Brown ^[3] ; Christian B,Willberg ^[6] ; Nneka,Nwokolo ^[7] ; Julie,Fox ^[8] ; Sarah,Fidler ^[9] ; W Nicholas,Haining ^[10] ; John,Frater ^[6]

作者单位： Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.;Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia. ^[1] Department of Immunology, Harvard Medical School, Boston, MA, United States.;Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, United States. ^[2] Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. ^[3] Department of Paediatrics, University of Oxford, Oxford, United Kingdom. ^[4] Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.;Division of Medicine, Wright Fleming Institute, Imperial College, London, United Kingdom. ^[5] Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.;Oxford National Institute of Health Research Biomedical Research Centre, Oxford, United Kingdom. ^[6] Chelsea and Westminster Hospital, London, United Kingdom. ^[7] Department of Genitourinary Medicine and Infectious Disease, Guys and St Thomas' National Health Service (NHS) Trust, London, United Kingdom.;King's College National Institute of Health Research (NIHR) Biomedical Research Centre, London, United Kingdom. ^[8] Division of Medicine, Wright Fleming Institute, Imperial College, London, United Kingdom.;Imperial College NIHR Biomedical Research Centre, London, United Kingdom. ^[9] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.;Discovery Oncology and Immunology, Merck Research Laboratories, Boston, MA, United States. ^[10]

关键词 Antiretroviral therapy (ART)HIV Immune exhaustion Primary HIV infection (PHI)T cells