Quadruplex Folding Promotes the Condensation of Linker Histones and DNAs via Liquid-Liquid Phase Separation.

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作者： Masahiro,Mimura ^[1] ; Shunsuke,Tomita ^[2] ; Yoichi,Shinkai ^[2] ; Takuya,Hosokai ^[3] ; Hiroyuki,Kumeta ^[4] ; Tomohide,Saio ^[5] ; Kentaro,Shiraki ^[6] ; Ryoji,Kurita ^[1]

作者单位： Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan. ^[1] Health and Medical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. ^[2] Biomedical Research Institute, AIST, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. ^[3] National Metrology Institute, AIST, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan. ^[4] Faculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido 060-0810, Japan. ^[5] Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. ^[6] DAILAB, DBT-AIST International Center for Translational and Environmental Research (DAICENTER), AIST, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan. ^[7]

主题词氨基酸序列(Amino Acid Sequence);DNA(DNA);G四链体(G-Quadruplexes);异染色质(Heterochromatin);组蛋白类(Histones);蛋白质结合(Protein Binding)

DOI 10.1021/jacs.1c03447

PMID 34152774

发布时间 2022-03-04

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