Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles.

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作者： Sonu,Kumar ^[1] ; Xiaohe,Lin ^[2] ; Timothy,Ngo ^[2] ; Benjamin,Shapero ^[2] ; Cindy,Sou ^[2] ; Joel D,Allen ^[3] ; Jeffrey,Copps ^[2] ; Lei,Zhang ^[2] ; Gabriel,Ozorowski ^[1] ; Linling,He ^[2] ; Max,Crispin ^[3] ; Andrew B,Ward ^[1] ; Ian A,Wilson ^[4] ; Jiang,Zhu ^[5]

作者单位： Department of Integrative Structural and Computational Biology, The Scripps Research Institutegrid.214007.0, La Jolla, California, USA.;IAVI Neutralizing Antibody Center, The Scripps Research Institutegrid.214007.0, La Jolla, California, USA.;Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institutegrid.214007.0, La Jolla, California, USA. ^[1] Department of Integrative Structural and Computational Biology, The Scripps Research Institutegrid.214007.0, La Jolla, California, USA. ^[2] School of Biological Sciences, University of Southamptongrid.5491.9, Southampton, United Kingdom. ^[3] Department of Integrative Structural and Computational Biology, The Scripps Research Institutegrid.214007.0, La Jolla, California, USA.;IAVI Neutralizing Antibody Center, The Scripps Research Institutegrid.214007.0, La Jolla, California, USA.;Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institutegrid.214007.0, La Jolla, California, USA.;Skaggs Institute for Chemical Biology, The Scripps Research Institutegrid.214007.0, La Jolla, California, USA. ^[4] Department of Integrative Structural and Computational Biology, The Scripps Research Institutegrid.214007.0, La Jolla, California, USA.;Department of Immunology and Microbiology, The Scripps Research Institutegrid.214007.0, La Jolla, California, USA. ^[5]

关键词 HIV-1 vaccine design envelope trimer glycan holes gp41 stabilization nanoparticle neutralizing antibodies