Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain.

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第一作者： Georg,Hahn

第一单位： Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.

作者： Georg,Hahn ^[1] ; Chloe M,Wu ^[2] ; Sanghun,Lee ^[1] ; Sharon M,Lutz ^[3] ; Surender,Khurana ^[1] ; Lindsey R,Baden ^[4] ; Sebastien,Haneuse ^[5] ; Dandi,Qiao ^[6] ; Julian,Hecker ^[1] ; Dawn L,DeMeo ^[7] ; Rudolph E,Tanzi ^[8] ; Manish C,Choudhary ^[4] ; Behzad,Etemad ^[7] ; Abbas,Mohammadi ^[7] ; Elmira,Esmaeilzadeh ^[8] ; Michael H,Cho ^[9] ; Jonathan Z,Li ^[7] ; Adrienne G,Randolph ^[7] ; Nan M,Laird ^[7] ; Scott T,Weiss ^[7] ; Edwin K,Silverman ^[7] ; Katharina,Ribbeck ^[8] ; Christoph,Lange ^[7]

作者单位： Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA. ^[1] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. ^[2] Department of Medical Consilience, Graduate School, Dankook University, Yongin, South Korea. ^[3] PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA. ^[4] Food and Drug Administration, Silver Spring, Maryland, USA. ^[5] Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA. ^[6] Harvard Medical School, Harvard University, Boston, Massachusetts, USA. ^[7] Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. ^[8] Genetics and Aging Research Unit, McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. ^[9] Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA. ^[10]

关键词 GISAID database SARS-CoV-2 logistic regression mortality spike protein whole-genome sequencing

主题词巴西(Brazil);全基因组关联研究(Genome-Wide Association Study);人类(Humans);突变(Mutation);种系发生(Phylogeny)

DOI 10.1002/gepi.22421

PMID 34159627

发布时间 2022-07-16

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