Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome.

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作者： Sridhar,Sreeramulu ^[1] ; Christian,Richter ^[1] ; Hannes,Berg ^[1] ; Maria A,Wirtz Martin ^[1] ; Betül,Ceylan ^[1] ; Tobias,Matzel ^[1] ; Jennifer,Adam ^[1] ; Nadide,Altincekic ^[1] ; Kamal,Azzaoui ^[2] ; Jasleen Kaur,Bains ^[1] ; Marcel J J,Blommers ^[2] ; Jan,Ferner ^[1] ; Boris,Fürtig ^[1] ; Michael,Göbel ^[1] ; J Tassilo,Grün ^[1] ; Martin,Hengesbach ^[1] ; Katharina F,Hohmann ^[1] ; Daniel,Hymon ^[1] ; Bozana,Knezic ^[1] ; Jason N,Martins ^[1] ; Klara R,Mertinkus ^[1] ; Anna,Niesteruk ^[1] ; Stephen A,Peter ^[3] ; Dennis J,Pyper ^[1] ; Nusrat S,Qureshi ^[1] ; Ute,Scheffer ^[4] ; Andreas,Schlundt ^[1] ; Robbin,Schnieders ^[5] ; Elke,Stirnal ^[1] ; Alexey,Sudakov ^[1] ; Alix,Tröster ^[1] ; Jennifer,Vögele ^[1] ; Anna,Wacker ^[5] ; Julia E,Weigand ^[1] ; Julia,Wirmer-Bartoschek ^[3] ; Jens,Wöhnert ^[1] ; Harald,Schwalbe ^[5]

作者单位： Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany. ^[1] Saverna Therapeutics, Pumpmattenweg 3, 4105, Biel-Benken, Switzerland. ^[2] Department of Biology, Technical University of Darmstadt, Schnittspahnstr. 10, 64287, Darmstadt, Germany. ^[3] Present address: EMBL Heidelberg, Meyerhofstr. 1, 69117, Heidelberg, Germany. ^[4] Institute for Molecular Biosciences, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University, Max-von-Laue-Str. 7+9, 60438, Frankfurt/M., Germany. ^[5]

关键词 Covid19-nmr NMR spectroscopy RNA SARS-CoV-2 fragment screening

主题词药物评价, 临床前(Drug Evaluation, Preclinical);基因组(Genome);配体(Ligands);分子结构(Molecular Structure);核酸构象(Nucleic Acid Conformation);RNA, 病毒(RNA, Viral);小分子化合物库(Small Molecule Libraries)

DOI 10.1002/anie.202103693

PMID 34161644

发布时间 2023-11-07

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