Absence of Non-Canonical, Inhibitory <i>MYD88</i> Splice Variants in B Cell Lymphomas Correlates With Sustained NF-κB Signaling.

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作者： Yamel,Cardona Gloria ^[1] ; Stephan H,Bernhart ^[2] ; Sven,Fillinger ^[3] ; Olaf-Oliver,Wolz ^[1] ; Sabine,Dickhöfer ^[1] ; Jakob,Admard ^[4] ; Stephan,Ossowski ^[4] ; Sven,Nahnsen ^[3] ; Reiner,Siebert ^[5] ; Alexander N R,Weber ^[6]

作者单位： Department of Immunology, University of Tübingen, Tübingen, Germany.;Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, Tübingen, Germany. ^[1] Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.;Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.;Transcriptome Bioinformatics, Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Leipzig, Germany. ^[2] Quantitative Biology Center (QBiC), University of Tübingen, Tübingen, Germany. ^[3] Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany. ^[4] Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.;Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany. ^[5] Department of Immunology, University of Tübingen, Tübingen, Germany.;Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, Tübingen, Germany.;Deutsches Konsortium für Translationale Krebsforschung (DKTK; German Cancer Consortium), Partner Site Tübingen, Department of Immunology, University of Tübingen, Tübingen, Germany. ^[6]

关键词 B cell lymphoma DLBCL - diffuse large B cell lymphoma MYD88 NF- kappa B TLR - Toll-like receptor alternative splicing negative feedback loop