PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia.

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第一作者： Inge,Govaerts

第一单位： Center for Human Genetics, KU Leuven, Leuven, Belgium.

作者： Inge,Govaerts ^[1] ; Cristina,Prieto ^[2] ; Charlien,Vandersmissen ^[3] ; Olga,Gielen ^[1] ; Kris,Jacobs ^[2] ; Sarah,Provost ^[3] ; David,Nittner ^[1] ; Johan,Maertens ^[2] ; Nancy,Boeckx ^[3] ; Kim,De Keersmaecker ^[1] ; Heidi,Segers ^[2] ; Jan,Cools ^[3]

作者单位： Center for Human Genetics, KU Leuven, Leuven, Belgium. ^[1] Center for Cancer Biology, VIB, Leuven, Belgium. ^[2] Leuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven, Belgium. ^[3] Department of Hematology, UZ Leuven, Leuven, Belgium. ^[4] Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. ^[5] Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium. ^[6] Department of Oncology, KU Leuven, Leuven, Belgium. ^[7] Department of Pediatric Oncology, UZ Leuven, Leuven, Belgium. ^[8] Center for Human Genetics, KU Leuven, Leuven, Belgium. jan.cools@kuleuven.be. ^[9] Center for Cancer Biology, VIB, Leuven, Belgium. jan.cools@kuleuven.be. ^[10] Leuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven, Belgium. jan.cools@kuleuven.be. ^[11]

关键词 Gamma-secretase complex Leukemia Mouse models Nuclear export Oncogenes Signaling Targeted therapy Toxicity