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首页> JHEP reports : innovation in hepatology> A phase II study of human allogeneic liver-derived progenitor cell therapy for acute-on-chronic liver failure and acute decompensation.

A phase II study of human allogeneic liver-derived progenitor cell therapy for acute-on-chronic liver failure and acute decompensation.

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第一作者： Frederik,Nevens
第一单位： Department of Gastroenterology and Hepatology, University Hospitals, KU Leuven, Belgium.
作者： Frederik,Nevens [1] ; Thierry,Gustot [2] ; Pierre-François,Laterre [3] ; Luc L,Lasser [4] ; Lyudmil E,Haralampiev [5] ; Victor,Vargas [6] ; Desislava,Lyubomirova [7] ; Agustin,Albillos [8] ; Mustapha,Najimi [9] ; Sébastien,Michel [10] ; Ivaylo,Stoykov [10] ; Noelia,Gordillo [10] ; Yelena,Vainilovich [10] ; Virginie,Barthel [10] ; Nathalie,Clerget-Chossat [10] ; Etienne M,Sokal [11]
作者单位： Department of Gastroenterology and Hepatology, University Hospitals, KU Leuven, Belgium. [1] Department of Gastroenterology and Hepato-Pancreatology, C.U.B. Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. [2] Intensive Care Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium. [3] Gastroenterology Clinic, CHU Brugmann, Brussels, Belgium.;Department of Hepatogastroenterology, CHU Brugmann, Brussels, Belgium. [4] Department of Internal Diseases, Multiprofile Hospital for Active Treatment (MEDICA), Ruse, Bulgaria. [5] Liver Unit, Hospital Vall d'Hebron, Universitat Autònoma Barcelona, CIBERehd, Barcelona, Spain. [6] Department of Clinical Gastroenterology with Hepatology, Gastroenterology Clinic, University Multiprofile Hospital for Active Treatment "Georgi Stranski", Pleven, Bulgaria. [7] Gastroenterology and Hepatology, University Hospital Ramón y Cajal, Madrid, Spain. [8] UCLouvain, Institute of Experimental and Clinical Research (IREC), Laboratory of Pediatric Hepatology and Cell Therapy (PEDI), Brussels, Belgium. [9] Promethera Biosciences, Mont-Saint-Guibert, Belgium. [10] UCLouvain, Institute of Experimental and Clinical Research (IREC), Laboratory of Pediatric Hepatology and Cell Therapy (PEDI), Brussels, Belgium.;Promethera Biosciences, Mont-Saint-Guibert, Belgium.;Cliniques Universitaires Saint-Luc, UCLouvain, Pediatric Hepatology & Gastroenterology Unit, Brussels, Belgium. [11]
关键词 ACLF, acute-on-chronic liver failureAD, acute decompensation of liver cirrhosisAE, adverse eventAESI, AE of special interestATMP, advanced therapy medicinal productAlcoholic liver diseaseBW, body weightCRP, C-reactive proteinEASL-CLIF, European Association for the Study of Chronic Liver FailureHALPC, human allogeneic liver-derived progenitor cellsINR, international normalised ratioLiver regenerative medicineMELD, model for end-stage liver diseaseMSC, mesenchymal stem cellsSAE, serious AESAS, safety analysis setSUSAR, suspected unexpected serious adverse reactionStem cellTEG, thromboelastographyTGT, thrombin generation testi.v., intravenous
DOI 10.1016/j.jhepr.2021.100291
PMID 34169246
发布时间 2024-07-09
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