Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory.

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第一作者： Valeria,Ramaglia

第一单位： Department of Axonal Signaling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands. v.ramaglia@utoronto.ca.;Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. v.ramaglia@utoronto.ca.

作者： Valeria,Ramaglia ^[1] ; Mohit,Dubey ^[2] ; M Alfonso,Malpede ^[2] ; Naomi,Petersen ^[2] ; Sharon I,de Vries ^[2] ; Shanzeh M,Ahmed ^[3] ; Dennis S W,Lee ^[3] ; Geert J,Schenk ^[4] ; Stefan M,Gold ^[5] ; Inge,Huitinga ^[6] ; Jennifer L,Gommerman ^[3] ; Jeroen J G,Geurts ^[4] ; Maarten H P,Kole ^[7]

作者单位： Department of Axonal Signaling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands. v.ramaglia@utoronto.ca.;Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. v.ramaglia@utoronto.ca. ^[1] Department of Axonal Signaling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands. ^[2] Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. ^[3] Department of Anatomy and Neurosciences, Amsterdam University Medical Center, Vrij Universiteit, MS Center Amsterdam, De Boelelaan 1108, 1007 MB, Amsterdam, The Netherlands. ^[4] Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.;Institut Für Neuroimmunologie Und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany. ^[5] Department of Neuroimmunology, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands. ^[6] Department of Axonal Signaling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands. m.kole@nin.knaw.nl.;Cell Biology, Biophysics and Neurobiology, Department of Biology, Faculty of Science, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands. m.kole@nin.knaw.nl. ^[7]

关键词 Complement Demyelination Hippocampus Microglia Multiple sclerosis Synapses