Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors.

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第一作者： Yui,Kuroda

第一单位： Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Pain Control Research, The Jikei University School of Medicine, Tokyo, Japan.

作者： Yui,Kuroda ^[1] ; Miki,Nonaka ^[2] ; Yuji,Kamikubo ^[3] ; Haruo,Ogawa ^[4] ; Takashi,Murayama ^[3] ; Nagomi,Kurebayashi ^[3] ; Hakushun,Sakairi ^[3] ; Kanako,Miyano ^[5] ; Akane,Komatsu ^[1] ; Tetsushi,Dodo ^[6] ; Kyoko,Nakano-Ito ^[7] ; Keisuke,Yamaguchi ^[8] ; Takashi,Sakurai ^[3] ; Masako,Iseki ^[9] ; Masakazu,Hayashida ^[9] ; Yasuhito,Uezono ^[10]

作者单位： Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Pain Control Research, The Jikei University School of Medicine, Tokyo, Japan. ^[1] Department of Pain Control Research, The Jikei University School of Medicine, Tokyo, Japan. ^[2] Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, Japan. ^[3] Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan. ^[4] Department of Pain Control Research, The Jikei University School of Medicine, Tokyo, Japan; Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, Japan. ^[5] Strategy Planning & Operations, Medicine Development Center, Eisai Co., Ltd., Ibaraki, Japan. ^[6] Global Drug Safety, Medicine Development Center, Eisai Co., Ltd., Ibaraki, Japan. ^[7] Department of Pain Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. ^[8] Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Pain Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. ^[9] Department of Pain Control Research, The Jikei University School of Medicine, Tokyo, Japan; Department of Pain Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Supportive and Palliative Care Research Support Office, National Center Hospital East, Chiba, Japan; Project for Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo, Japan. Electronic address: yuezono@jikei.ac.jp. ^[10]

关键词 Analgesic BQ-123 sodium salt (PubChem CID: 52943236)BQ-788 sodium salt (PubChem CID: 23693553)Endothelin A receptor antagonist G protein-coupled receptor Morphine Pain Receptor heterodimerization and Bosentan Monohydrate (PubChem CID: 185462)included endothelin-1 (PubChem CID: 16212950)morphine hydrochloride (PubChem CID: 5464110)