首页> Heart rhythm> Deficiency of CXXC finger protein 1 leads to small changes in heart rate but moderate epigenetic alterations and significant protein downregulation of hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) ion channels in mice.

Deficiency of CXXC finger protein 1 leads to small changes in heart rate but moderate epigenetic alterations and significant protein downregulation of hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) ion channels in mice.

导出 LinkOut

翻译打印收藏纠错

第一作者： Ling,Shi

第一单位： Department of Pharmacology (The Key Laboratory of Cardiovascular Research, Ministry of Education) at College of Pharmacy, Harbin Medical University, Harbin, China.

作者： Ling,Shi ^[1] ; Jingling,Shen ^[2] ; Xuexin,Jin ^[1] ; Zheng,Li ^[1] ; Jiudong,Ma ^[1] ; Xiang,Huang ^[1] ; Yang,Guo ^[1] ; Wenbo,Ma ^[1] ; Dongmei,Gong ^[1] ; Baofeng,Yang ^[1] ; Zhenwei,Pan ^[3]

作者单位： Department of Pharmacology (The Key Laboratory of Cardiovascular Research, Ministry of Education) at College of Pharmacy, Harbin Medical University, Harbin, China. ^[1] Institute of Life Sciences, Wenzhou University, Wenzhou, China; College of Life and Environmental Sciences, Wenzhou University, Wenzhou, China. ^[2] Department of Pharmacology (The Key Laboratory of Cardiovascular Research, Ministry of Education) at College of Pharmacy, Harbin Medical University, Harbin, China; Key Laboratory of Cell Transplantation, The First Affiliated Hospital, Harbin Medical University, Harbin, China. Electronic address: panzw@ems.hrbmu.edu.cn. ^[3]

关键词 CXXC finger protein 1 Epigenetic modification Hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4)I(f) current Sinus bradycardia