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A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.

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作者单位: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. mina.jhun82@gmail.com.;Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. mina.jhun82@gmail.com. [1] Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.;Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. [2] Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.;Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany. [3] Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. [4] Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. [5] Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. [6] The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. [7] Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. [8] Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA. [9] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [10] Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. [11] Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.;GENYO, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain. [12] Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA. [13] Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA. [14] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. [15] Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.;Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. [16] Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. [17] School of Public Health, University of Texas Health Science Center at Houston, Huston, TX, USA. [18] Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA. [19] Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.;IBE, Faculty of Medicine, LMU Munich, Munich, Germany.;Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany. [20] Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.;Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.;Institute of Human Genetics, Technical University Munich, Munich, Germany. [21] Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.;Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany. [22] Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. [23] Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.;Survey Research Center, Institute for Social Research, Ann Arbor, MI, USA. [24] Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA. [25] Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands. [26] School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA. [27] Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.;Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China. [28] Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK. [29] Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. [30] HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA. [31] Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.;Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA. [32] Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.;VA Palo Alto Healthcare System, Palo Alto, CA, USA.;Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. [33] Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA, USA.;Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. [34] Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA. [35] Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.;Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.;Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.;Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. [36] Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.;Department of Biostatistics and Epidemiology, MRC Centre for Environment and Health, School of Public Health, Imperial College, London, UK. [37] Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. [38] Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.;Department of Medicine, University of North Carolina, Chapel Hill, NC, USA. [39] Department of Environmental Health Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA. [40] Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.;Framingham Heart Study, Framingham, MA, USA. [41] Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. tassimes@stanford.edu.;VA Palo Alto Healthcare System, Palo Alto, CA, USA. tassimes@stanford.edu.;Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. tassimes@stanford.edu. [42]
DOI 10.1038/s41467-021-23899-y
PMID 34183656
发布时间 2024-09-06
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