CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation.

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作者： Xueyu,Wang ^[1] ; Zhiqiang,Wei ^[2] ; Tingyu,Lan ^[1] ; Yulin,He ^[2] ; Bin,Cheng ^[1] ; Ruimin,Li ^[3] ; Hongxia,Chen ^[1] ; Fahong,Li ^[1] ; Guohua,Liu ^[1] ; Bin,Jiang ^[1] ; Yong,Lin ^[2] ; Mengji,Lu ^[4] ; Zhongji,Meng ^[1]

作者单位： Institute of Biomedical Research, Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei province, China. ^[1] Institute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. ^[2] Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei province, China. ^[3] Department of Infectious Diseases,Huashan Hospital, Fudan University, Shanghai, China. ^[4] Department of Hepatobiliary Pancreatic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei province, China. ^[5] The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. ^[6] Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei province, China. ^[7]

关键词 Autophagic degradation DNM2 GNAI3 autophagosomal trafficking endosomal trafficking hepatitis B virus