Transcriptionally inactive hepatitis B virus episome DNA preferentially resides in the vicinity of chromosome 19 in 3D host genome upon infection.

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作者： Dingbin,Tang ^[1] ; Hanqing,Zhao ^[2] ; Yumeng,Wu ^[1] ; Bo,Peng ^[1] ; Zhenchao,Gao ^[2] ; Yinyan,Sun ^[2] ; Jinzhi,Duan ^[2] ; Yonghe,Qi ^[2] ; Yunfei,Li ^[2] ; Zhongmin,Zhou ^[3] ; Guilan,Guo ^[3] ; Yu,Zhang ^[2] ; Cheng,Li ^[4] ; Jianhua,Sui ^[5] ; Wenhui,Li ^[6]

作者单位： Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, School of Life Sciences, Peking University, Beijing, China; National Institute of Biological Sciences, Beijing, China. ^[1] National Institute of Biological Sciences, Beijing, China. ^[2] College of Life Sciences, Beijing Normal University, Beijing, China; National Institute of Biological Sciences, Beijing, China. ^[3] School of Life Sciences, Center for Statistical Science, Center for Bioinformatics, Peking University, Beijing, China. ^[4] National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. ^[5] National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. Electronic address: liwenhui@nibs.ac.cn. ^[6]

关键词 3D host genome HBV HBx protein cccDNA chromosome 19 circularized chromosome conformation capture (4C) sequencing analysis episomal DNA fluorescence in situ hybridization (FISH)in situ Hi-C analysis spatial localization