Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway.

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作者： Mohamed Gamal El-Din,Ewees ^[1] ; Mohamed Sadek,Abdel-Bakky ^[2] ; Asmaa Mostafa Ahmed,Bayoumi ^[3] ; Ali Ahmed,Abo-Saif ^[4] ; Waleed Mohammad,Altowayan ^[5] ; Khalid Saad,Alharbi ^[6] ; Basim Anwar Shehata,Messiha ^[7]

作者单位： Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt. ^[1] Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, Saudi Arabia. ^[2] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. ^[3] Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt. ^[4] Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. ^[5] Department of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim, Saudi Arabia. ^[6] Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia. ^[7] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt. ^[8]

主题词动物(Animals);抗凝血酶类(Antithrombins);细胞凋亡(Apoptosis);血尿素氮(Blood Urea Nitrogen);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);顺铂(Cisplatin);减量调节(Down-Regulation);肾(Kidney);肾疾病(Kidney Diseases);MAP激酶信号系统(MAP Kinase Signaling System);男(雄)性(Male);肿瘤(Neoplasms);氧化性应激(Oxidative Stress);大鼠(Rats);凝血酶(Thrombin);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1016/j.jare.2020.12.014

PMID 34194837

发布时间 2022-04-24

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Journal of advanced research

2021年31卷

127-136页

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Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway.

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Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway.

Journal of advanced research

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Journal of advanced research

相关期刊

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