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首页> Neuropharmacology> Downregulation of astroglial glutamate transporter GLT-1 in the lateral habenula is associated with depressive-like behaviors in a rat model of Parkinson's disease.

Downregulation of astroglial glutamate transporter GLT-1 in the lateral habenula is associated with depressive-like behaviors in a rat model of Parkinson's disease.

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作者： Shuxuan,Lyu ^[1] ; Yuan,Guo ^[1] ; Li,Zhang ^[1] ; Guoyi,Tang ^[1] ; Ruotong,Li ^[1] ; Jie,Yang ^[1] ; Shasha,Gao ^[1] ; Wenjuan,Li ^[2] ; Jian,Liu ^[3]

作者单位： Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China. ^[1] Department of Rehabilitation Medicine, The Second Hospital, Xi'an Jiaotong University, Xi'an, 710004, China. ^[2] Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China. Electronic address: liujian@mail.xjtu.edu.cn. ^[3]

关键词 Astrocytes GLT-1 Lateral habenula Neuron-glial communication PD-Related depression

主题词动物(Animals);星形细胞(Astrocytes);抑郁(Depression);疾病模型, 动物(Disease Models, Animal);减量调节(Down-Regulation);兴奋性氨基酸转运子2(Excitatory Amino Acid Transporter 2);谷氨酸(Glutamic Acid);缰(Habenula);羟多巴胺(Oxidopamine);帕金森障碍(Parkinsonian Disorders);大鼠(Rats);黑质(Substantia Nigra);丘脑(Thalamus);腹侧被盖区(Ventral Tegmental Area)

DOI 10.1016/j.neuropharm.2021.108691

PMID 34197892

发布时间 2022-02-02

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