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Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2.

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第一作者： Denis O,Shatalov

第一单位： Institute of Fine Chemical Technologies Named after Lomonosov, MIREA-Russian Technological University, 119571 Moscow, Russia.

作者： Denis O,Shatalov ^[1] ; Stanislav A,Kedik ^[1] ; Ivan S,Ivanov ^[1] ; Anna V,Aydakova ^[2] ; Diana A,Akhmedova ^[2] ; Dmitrii S,Minenkov ^[3] ; Sergei V,Beliakov ^[1] ; Alexander,Herbst ^[4] ; Lasse,Greiner ^[5] ; Liubov I,Kozlovskaya ^[6] ; Viktor P,Volok ^[7]

作者单位： Institute of Fine Chemical Technologies Named after Lomonosov, MIREA-Russian Technological University, 119571 Moscow, Russia. ^[1] Institute of Fine Chemical Technologies Named after Lomonosov, MIREA-Russian Technological University, 119571 Moscow, Russia.;Institute of Pharmaceutical Technology, 119571 Moscow, Russia. ^[2] Ishlinsky Institute for Problems in Mechanics RAS, 119526 Moscow, Russia. ^[3] Wingflow AG, Gaensaker 5, 5070 Frick, Switzerland. ^[4] Mannheim University of Applied Sciences, 68163 Mannheim, Germany. ^[5] FSBSI "Chumakov FSC R&D IBP RAS", 108819 Moscow, Russia.;Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, 117418 Moscow, Russia. ^[6] FSBSI "Chumakov FSC R&D IBP RAS", 108819 Moscow, Russia. ^[7]

关键词 antimicrobial resistance antiseptic antiviral activity microfluidics microreactor polycondensation

主题词动物(Animals);抗病毒药(Antiviral Agents);胍类(Guanidines);半数抑制浓度(Inhibitory Concentration 50);微流体学(Microfluidics);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization);Vero细胞(Vero Cells)

DOI 10.3390/molecules26113472

PMID 34200418

发布时间 2024-04-02

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