The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner.

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作者： Victoria,Callahan ^[1] ; Seth,Hawks ^[2] ; Matthew A,Crawford ^[3] ; Caitlin W,Lehman ^[2] ; Holly A,Morrison ^[2] ; Hannah M,Ivester ^[4] ; Ivan,Akhrymuk ^[2] ; Niloufar,Boghdeh ^[1] ; Rafaela,Flor ^[1] ; Carla V,Finkielstein ^[5] ; Irving Coy,Allen ^[2] ; James,Weger-Lucarelli ^[6] ; Nisha,Duggal ^[7] ; Molly A,Hughes ^[2] ; Kylene,Kehn-Hall ^[7]

作者单位： National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, USA. ^[1] Department of Biomedical Science and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA. ^[2] Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA. ^[3] Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA 24061, USA. ^[4] Integrated Cellular Responses Laboratory, Department of Biological Sciences and Center for Drug Discovery, Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, VA 24016, USA. ^[5] Virginia Tech Carilion School of Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24016, USA. ^[6] Center for Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA. ^[7]

关键词 ALI ARDS CXCL10 Calu-3 SARS-CoV-2 betacoronavirus cytokine storm hACE2 mice