Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells.

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作者： Alexis,Rugamba ^[1] ; Dong Young,Kang ^[1] ; Nipin,Sp ^[1] ; Eun Seong,Jo ^[2] ; Jin-Moo,Lee ^[2] ; Se Won,Bae ^[3] ; Kyoung-Jin,Jang ^[1]

作者单位： Department of Pathology, Institute of Biomedical Science and Technology, School of Medicine, Konkuk University, Chungju 27478, Korea. ^[1] Pharmacological Research Division, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex, Cheongju-si 28159, Korea. ^[2] Department of Chemistry and Cosmetics, Jeju National University, Jeju 63243, Korea. ^[3]

关键词 EGFR JAK2/STAT5b MMP2 NSCLC PD-L1 PI3K/AKT silibinin tumorsphere

主题词细胞凋亡(Apoptosis);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);疾病恶化(Disease Progression);人类(Humans);肺肿瘤(Lung Neoplasms);模型, 生物学(Models, Biological);肿瘤侵润(Neoplasm Invasiveness);肿瘤干细胞(Neoplastic Stem Cells);新生血管化, 生理性(Neovascularization, Physiologic);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);STAT5转录因子(STAT5 Transcription Factor);球形体, 细胞(Spheroids, Cellular)

DOI 10.3390/cells10071632

PMID 34209829

发布时间 2021-10-27

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2021年10卷7期

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Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells.

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Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells.

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