SENTI-101, a Preparation of Mesenchymal Stromal Cells Engineered to Express IL12 and IL21, Induces Localized and Durable Antitumor Immunity in Preclinical Models of Peritoneal Solid Tumors.
第一作者:
Alba,Gonzalez-Junca
第一单位:
Department of Research and Development, Senti Biosciences, Inc., South San Francisco, California. alba.gonzalez@sentibio.com.
作者:
医学主题词
动物(Animals);细胞凋亡(Apoptosis);细胞增殖(Cell Proliferation);女(雌)性(Female);人类(Humans);白细胞介素12(Interleukin-12);白细胞介素类(Interleukins);黑色素瘤, 实验性(Melanoma, Experimental);间质干细胞移植(Mesenchymal Stem Cell Transplantation);间质干细胞(Mesenchymal Stem Cells);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 裸(Mice, Nude);肿瘤(Neoplasms);腹膜肿瘤(Peritoneal Neoplasms);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/1535-7163.MCT-21-0030
PMID
34210826
发布时间
2025-01-03
- 浏览3
Molecular cancer therapeutics
1508-1520页
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