Effect of acute and chronic exposure to lovastatin on the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.

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第一作者： Michał,Tomaszewski

第一单位： Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20-090, Lublin, Poland; Department of Cardiology, Medical University of Lublin, Jaczewskiego 8, 20-090, Lublin, Poland.

作者： Michał,Tomaszewski ^[1] ; Dorota,Zolkowska ^[2] ; Zbigniew,Plewa ^[3] ; Stanisław J,Czuczwar ^[4] ; Jarogniew J,Łuszczki ^[5]

作者单位： Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20-090, Lublin, Poland; Department of Cardiology, Medical University of Lublin, Jaczewskiego 8, 20-090, Lublin, Poland. ^[1] Department of Neurology, UC Davis School of Medicine, 4635 2nd Avenue, Sacramento, CA, 95817, USA. ^[2] Department of General, Oncological and Minimally Invasive Surgery, 1st Military Clinical Hospital, Lublin, Poland. ^[3] Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20-090, Lublin, Poland. ^[4] Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20-090, Lublin, Poland. Electronic address: jarogniew.luszczki@umlub.pl. ^[5]

关键词 Antiepileptic drugs Lovastatin Maximal electroshock-induced seizures Pharmacokinetic/pharmacodynamic interaction