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A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals.

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第一作者： Jaewon,Yang

第一单位： Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea.

作者： Jaewon,Yang ^[1] ; Alexander,König ^[1] ; Soonju,Park ^[2] ; Eunji,Jo ^[1] ; Pil Soo,Sung ^[3] ; Seung Kew,Yoon ^[3] ; Eva,Zusinaite ^[4] ; Denis,Kainov ^[5] ; David,Shum ^[2] ; Marc Peter,Windisch ^[6]

作者单位： Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea. ^[1] Screening Discovery Platform, Institut Pasteur Korea, Seongnam-si, South Korea. ^[2] Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.;Catholic University Liver Research Center, The Catholic University of Korea, Seoul, South Korea. ^[3] Institute of Technology, University of Tartu, Tartu, Estonia. ^[4] Institute of Technology, University of Tartu, Tartu, Estonia.;Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. ^[5] Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea.;Division of Bio-Medical Science and Technology, University of Science and Technology, Daejeon, South Korea. ^[6]

关键词 CV, percent coefficient of variation Imax, percent maximum inhibition CC50, 50 cytotoxic concentration CHB, chronic hepatitis B CpAM, core protein allosteric modifiers DRC, dose–response curve Entry FDA, Food and Drug Administration FDA-approved drugs GEq, genome equivalents HBV HBVpt, patient-derived HBV HCC, hepatocellular carcinoma HCS, high content screening HID, N-hydroxyisoquinolinedione HLCs, hepatocyte-like cells HTS, high-throughput screening HepG2-NTCP High-throughput screening IFA, immunofluorescence analysis IFNα, interferon alpha IFNλ, interferon lambda LHB, HBV large surface protein LMV, lamivudine MoA, mechanism of action MyrB, myrcludex B NTCP, sodium taurocholate cotransporting polypeptide PEG, polyethylene glycol PF-rcDNA, protein-free relaxed circular DNA Patient-derived HBV Replication SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 SOP, standard operation procedure Small-molecule inhibitors Supernatant transfer TDF, tenofovir disoproxil fumarate TI, therapeutic index Virion secretion cccDNA, covalently closed circular DNA dpi, days post-infection iPSCs, induced pluripotent stem cells p1, passage 1 p2, passage 2 pgRNA, pregenomic RNA

DOI 10.1016/j.jhepr.2021.100296

PMID 34222850

发布时间 2022-04-24

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A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals.

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A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals.

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