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Study of chondroitin sulfate E oligosaccharide as a promising complement C5 inhibitor for osteoarthritis alleviation.

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第一作者： Chen,Yu

第一单位： Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

作者： Chen,Yu ^[1] ; Hengchang,Zang ^[2] ; Cui,Yang ^[1] ; Dong,Liang ^[1] ; Shuang,Quan ^[1] ; Danyang,Li ^[1] ; Yanni,Li ^[3] ; Qin,Dong ^[1] ; Fengshan,Wang ^[2] ; Lian,Li ^[4]

作者单位： Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. ^[1] Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Laboratory of Carbohydrate Chemistry and Glycobiology, National Glycoengineering Research Center, Shandong University, Jinan 250012, Shandong, China. ^[2] School of Pharmacy, Binzhou Medical University, Yantai 264003, China. ^[3] Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address: lilian@sdu.edu.cn. ^[4]

关键词 Chondroitin sulfate (CS) E oligosaccharide Complement C5 Complement system Membrane-attack complex (MAC)Osteoarthritis (OA)

医学主题词软骨素硫酸盐类(Chondroitin Sulfates);补体C5(Complement C5);补体灭活剂(Complement Inactivating Agents);人类(Humans);寡糖类(Oligosaccharides);骨关节炎(Osteoarthritis)

DOI 10.1016/j.msec.2021.112234

PMID 34225875

发布时间 2021-07-07

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