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Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques.

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作者单位: California National Primate Research Center, University of California, Davis, United States of America.;Department of Pathology, Microbiology and Immunology, University of California, Davis, California, United States of America. [1] California National Primate Research Center, University of California, Davis, United States of America. [2] Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, United States of America. [3] Center for Immunology and Infectious Diseases, University of California, Davis, California, United States of America. [4] Laboratory of Retrovirology, The Rockefeller University, New York, New York, United States of America. [5] Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America. [6] School of Veterinary Medicine, University of California, Davis, California, United States of America. [7] Translational Research Section, Virology Branch, DMID/NIAID/NIH, Rockville, Maryland, United States of America. [8] Preclinical Research and Development Branch, Vaccine Research Program, DAIDS/NIAID/NIH, Rockville, Maryland, United States of America. [9] Laboratory of Retrovirology, The Rockefeller University, New York, New York, United States of America.;Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America. [10] California National Primate Research Center, University of California, Davis, United States of America.;Department of Pathology, Microbiology and Immunology, University of California, Davis, California, United States of America.;Center for Immunology and Infectious Diseases, University of California, Davis, California, United States of America. [11] California National Primate Research Center, University of California, Davis, United States of America.;Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, United States of America. [12] Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America.;Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America. [13]
DOI 10.1371/journal.ppat.1009688
PMID 34228761
发布时间 2024-09-23
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