Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin-a novel tumor checkpoint controller targeting microtubules.

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第一作者： Danielle M,Burgenske

第一单位： Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.

作者： Danielle M,Burgenske ^[1] ; Surabhi,Talele ^[2] ; Jenny L,Pokorny ^[3] ; Ann C,Mladek ^[1] ; Katrina K,Bakken ^[1] ; Brett L,Carlson ^[1] ; Mark A,Schroeder ^[4] ; Lihong,He ^[1] ; Zeng,Hu ^[1] ; Gautham,Gampa ^[2] ; Matthew L,Kosel ^[5] ; Paul A,Decker ^[5] ; Gaspar J,Kitange ^[1] ; Anne,Schmitt-Hoffmann ^[6] ; Felix,Bachmann ^[7] ; Rachael A,Vaubel ^[5] ; Jeanette E,Eckel-Passow ^[7] ; Caterina,Giannini ^[6] ; Paul,McSheehy ^[6] ; Heidi A,Lane ^[2] ; William F,Elmquist ^[1] ; Jann N,Sarkaria

作者单位： Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA. ^[1] Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota, USA. ^[2] Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.;Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ^[3] Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA. ^[4] Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA. ^[5] Basilea Pharmaceutica International Ltd., Basel, Switzerland. ^[6] Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. ^[7]

关键词 drug efficacy glioblastoma microtubule-targeting agents patient-derived xenografts

主题词动物(Animals);抗肿瘤药, 烷基化(Antineoplastic Agents, Alkylating);脑肿瘤(Brain Neoplasms);胶质母细胞瘤(Glioblastoma);人类(Humans);小鼠(Mice);微管(Microtubules)

DOI 10.1093/neuonc/noab162

PMID 34232318

发布时间 2024-11-30

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