Development of 7SK snRNA Mimics That Inhibit HIV Transcription.

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作者： Asako,Yamayoshi ^[1] ; Hiroyuki,Fukumoto ^[2] ; Rie,Hayashi ^[2] ; Kyosuke,Kishimoto ^[2] ; Akio,Kobori ^[2] ; Yoshio,Koyanagi ^[3] ; Jun A,Komano ^[4] ; Akira,Murakami ^[2]

作者单位： Chemistry of Functional Molecules, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi Nagasaki-shi, Nagasaki, 852-8521, Japan. ^[1] Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki Sakyo-ku, Kyoto, 606-8585, Japan. ^[2] Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Shogoin-kawaramachi 53 Sakyo-ku, Kyoto, 606-8507, Japan. ^[3] Department of Microbiology and Infection Control, Faculty and Graduate School of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1041, Japan. ^[4]

关键词 7SK HIV non-coding RNA nucleic acid drug transcriptional inhibitor

主题词剂量效应关系, 药物(Dose-Response Relationship, Drug);分子结构(Molecular Structure);RNA, 小核(RNA, Small Nuclear);构效关系(Structure-Activity Relationship);转录, 遗传(Transcription, Genetic);tat基因产物, 人免疫缺陷病毒(tat Gene Products, Human Immunodeficiency Virus)

DOI 10.1002/cmdc.202100422

PMID 34233081

发布时间 2022-02-23

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