首页> JAMA oncology> Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.

Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.

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第一作者： Andrew J,Wagner

第一单位： Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

作者： Andrew J,Wagner ^[1] ; Paul L,Severson ^[2] ; Anthony F,Shields ^[3] ; Amita,Patnaik ^[4] ; Rashmi,Chugh ^[5] ; Gabriel,Tinoco ^[6] ; Guoxian,Wu ^[2] ; Marika,Nespi ^[2] ; Jack,Lin ^[2] ; Ying,Zhang ^[2] ; Todd,Ewing ^[2] ; Gaston,Habets ^[2] ; Elizabeth A,Burton ^[2] ; Bernice,Matusow ^[2] ; James,Tsai ^[2] ; Garson,Tsang ^[2] ; Rafe,Shellooe ^[2] ; Heidi,Carias ^[2] ; Katrina,Chan ^[2] ; Hamid,Rezaei ^[2] ; Laura,Sanftner ^[2] ; Adhirai,Marimuthu ^[2] ; Wayne,Spevak ^[2] ; Prabha N,Ibrahim ^[2] ; Kerry,Inokuchi ^[2] ; Oscar,Alcantar ^[2] ; Glenn,Michelson ^[7] ; Athanasios C,Tsiatis ^[2] ; Chao,Zhang ^[2] ; Gideon,Bollag ^[2] ; Jonathan C,Trent ^[8] ; William D,Tap ^[9]

作者单位： Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. ^[1] Plexxikon Inc, Berkeley, California. ^[2] Karmanos Cancer Institute, Wayne State University, Detroit, Michigan. ^[3] South Texas Accelerated Research Therapeutics, San Antonio. ^[4] University of Michigan, Ann Arbor. ^[5] The Ohio State University Comprehensive Cancer Center, Columbus. ^[6] Cogent Biosciences, Inc, Cambridge, Massachusetts. ^[7] Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida. ^[8] Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York. ^[9]

医学主题词胃肠道间质肿瘤(Gastrointestinal Stromal Tumors);人类(Humans);男(雄)性(Male);中年人(Middle Aged);突变(Mutation);肿瘤复发, 局部(Neoplasm Recurrence, Local);蛋白激酶抑制剂(Protein Kinase Inhibitors)

DOI 10.1001/jamaoncol.2021.2086

PMID 34236401

发布时间 2024-04-02

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JAMA oncology

2021年7卷9期

1343-1350页

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JAMA oncology

2021年7卷9期

1343-1350页

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Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.

JAMA oncology

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Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.

JAMA oncology

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JAMA oncology

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